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Chemical Structure : NITD-564
Catalog No.: PC-62532Not For Human Use, Lab Use Only.
NITD-564 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.59 uM, exhibits MIC50 of 160 nM against Mtb.
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NITD-564 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.59 uM, exhibits MIC50 of 160 nM against Mtb.
NITD-564 binds specifically to InhA in an NADH-dependent manner and blocks the enoyl substrate-binding pocket.
NITD-564 shows in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection.
| M.Wt | 283.371 | |
| Formula | C18H21NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Manjunatha UH, et al. Sci Transl Med. 2015 Jan 7;7(269):269ra3.
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