Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-45367	Fidaxomicin Antibiotic	Fidaxomicin (OPT-80, PAR-101) is a new class of narrow spectrum macrocyclic antibiotic drug and RNA polymerase inhibitor, shows potent anti-Clostridium difficile activity with MIC90 of 0.12 ug/mL.
PC-42715	Delamanid	Delamanid (OPC-67683) is a mycolic acid biosynthesis inhibitor found to be free of mutagenicity and to possess highly potent activity against tuberculosis, including MDR-TB.
PC-45263	Azathramycin Antibiotic	Azathramycin is a macrolide antibiotic that effectively inhibits tumor angiogenesis by suppressing VEGFR2-mediated signaling pathways in lung cancer.
PC-45638	Ribocil-C FMN riboswitch inhibitor	Ribocil-C is a highly selective inhibitor of the FMN riboswitch that controls expression of de novo riboflavin (Vitamin B2) biosynthesis in Escherichia coli.
PC-42665	Gatifloxacin Bacterial DNA gyrase inhibitor	Gatifloxacin (PD 135432, AM1155) is a fourth-generation fluoroquinolone antibiotic that inhibits the bacterial DNA gyrase and topoisomerase IV.
PC-42048	Faropenem daloxate Beta-lactam antibiotic	Faropenem daloxate (Faropenem medoxil) is a daloxate ester prodrug of Faropenem with broad-spectrum antibacterial activity against many gram-positive and gram-negative aerobes and anaerobes, a beta-lactam antibiotic.
PC-42714	PA-824 Antibiotic	Pretomanid (PA-824) is an anti-tuberculosis agent that inhibits the synthesis of protein and cell wall lipid.
PC-24471	TU-514 LpxC inhibitor	TU-514 is a substrate-analog inhibitor of zinc-dependent UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) with Ki of 3.9 uM for E. coli LpxC and IC50 of 7.0 uM (A. aeolicus LpxC)
PC-24470	L-573655 LpxC inhibitor	L-573655 (L-573,655) is a specific small molecule inhibitor of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC), inhibits E. coli LpxC with Ki values of 24 uM and approximately 50 nM, respectively.
PC-24466	JSF-4536 M.tb MenG inhibitor	JSF-4536 is a small molecule inhibitor of Mycobacterium tuberculosis methyltransferase MenG enzyme, inhibits menaquinone biosynthetic pathway, inhibits M. tuberculosis H37Rv strain with MIC of 0.78 uM.
PC-24465	JSF-4898 M.tb MenG inhibitor	JSF-4898 is a small molecule inhibitor of Mycobacterium tuberculosis methyltransferase MenG enzyme, inhibits menaquinone biosynthetic pathway, inhibits M. tuberculosis H37Rv strain with MIC of 0.78 uM.
PC-24460	IP6C Type II Thoeris system inhibitor	IP6C is a small molecule inhibitor of type II Thoeris systems encoded by multiple bacteria species, inhibits BaY2 Thoeris with IC50 of 10 uM, inhibits the type II Thoeris system by blocking His-ADPR production by ThsB.

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