| Cat. No. |
Product Name |
Information |
| PC-23524 |
REP8839
MetRS inhibitor
|
REP8839 (Bederocin) is a potent inhibitor of S. aureus methionyl-tRNA synthetase (MetRS) with IC50 of <1.9 nM. |
| PC-23523 |
DDD806905
MetRS inhibitor
|
DDD806905 is a highly potent, selective inhibitor of Leishmania donovani methionyl-tRNA synthetase (LdMetRS) with Ki of 18 nM. |
| PC-23456 |
Bedaquiline
Mycobacterial ATP synthase inhibitor
|
Bedaquiline fumarate (TMC207, R207910) is a diarylquinoline antibiotic that targets ATP synthase, inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit. |
| PC-23455 |
SQ31f
Mycobacterial ATP synthase inhibitor
|
SQ31f is a potent non-tuberculous mycobacteria antibiotic by specifically targeting the mycobacterial F-ATP synthase, inhibits ATP hydrolysis with IC50 of 0.6 uM. |
| PC-23309 |
MRS-2541
MetRS inhibitor
|
MRS-2541 a novel potent inhibitor of methionyl-tRNA synthetase (MetRS) with selective activity against gram-positive bacteria with MIC of 0.063-0.5 ug/mL against Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus species. |
| PC-23291 |
BTI (BrpT Inhibitor)
BrpT Inhibitor
|
BTI (BrpT Inhibitor) is a specific small molecule inhibitor of V. vulnificus transcriptional regulator BrpT with EC50 of 6.48 uM, without affecting bacterial growth or host cell viability. |
| PC-23266 |
CBR-5992
Mtb NDH-2 inhibitor
|
CBR-5992 is a small molecule of Mtb type II NADH dehydrogenase (NDH-2)) inhibitor with ATP IC50 of 2.2 ug/mL, shows MIC90 of 0.5 ug/ mL against Mtb H37Rv. |
| PC-23241 |
Zidebactam
β-lactam enhancer
|
Zidebactam (WCK-5107) is a β-Lactam Enhancer, inhibitor of class A, class C and some class D β-lactamases with MIC of <2 ug/ mL for most Escherichia coli , Klebsiella , Citrobacter and Enterobacter spp., also binds to penicillin-binding protein2 (PBP2). |
| PC-23224 |
Iclaprim
DHFR inhibitor
|
Iclaprim (AR-100) is a selective dihydrofolate reductase (DHFR) inhibitor, is active against methicillin, TMP and vancomycin resistant strains, has MIC90 of 0.5 ug/mL against C. trachomatis and C. pneumoniae. |
| PC-23214 |
IITR07865
MreB inhibitor
|
IITR07865 is a small molecule bactericidal compound that targets the MreB protein of the rod complex, induces oxidative stress in E. coli cells, exhibits growth inhibitory activity against a broad spectrum of Gram-negative rod-shaped bacteria, with MIC of 4-16 μg/mL for E. coli strains. |
| PC-23207 |
GSK138
InhA inhibitor
|
GSK138 (GSK3081138A) is a potent, direct inhibitor of M. tuberculosis InhA with IC50 of 0.04 uM, and MIC of 1 uM against M. tuberculosis H37Rv. |
| PC-23202 |
CHIR-090
LpxC inhibitor
|
CHIR-090 is a potent, slow, tight-binding inhibitor of the LpxC deacetylase, binds to E. coli LpxC with Ki of 4.0 nM, displays good antimicrobial activity against several Gram-negative bacteria. |
