Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-26828	MRL-494 hydrochloride BamA inhibitor	MRL-494 hydrochloride (MRL494) is an antimicrobial small molecule that inhibits assembly of outer membrane proteins (OMPs) by the β-barrel assembly machine (BAM complex), inhibits the insertion of OMPs into the OM by targeting BamA.
PC-26808	BRD1554 Mtb Pks13 inhibitor	BRD1554 is a selective inhibitor of Mycobacterium tuberculosis polyketide synthase 13 (Pks13).
PC-26780	Fluorothiazinone T3SS inhibitor, Anti-virulence	Fluorothiazinone is a small molecule antivirulent compound that suppresses the formation of biofilms, inhibits the type III secretion system (T3SS) in Gram-negative bacteria.
PC-26720	KGDI-109 PgDPP7 inhibitor	KGDI-109 is the first substrate-mimetic dipeptide inhibitor of P. gingivalis dipeptidyl peptidase 7 (PgDPP7) with IC50 of 53.8 uM and Ki of 25.1 uM, exerts an inhibitory effect against P. gingivalis growth with MIC of 1.56 uM.
PC-26708	BDM91531 AcrB efflux pump inhibitor	BDM91531 is a potent AcrB efflux pump inhibitor, binds to the TMD of the L state and O state protomers of AcrB, exhibits potent potentiation of pyridomycin activity with EC90 of 0.24 uM.
PC-26671	Funobactam β-lactamase inhibitor	Funobactam (XNW4107) is a novel β-lactamase inhibitor that possesses broad activity against serine-β-lactamases, displays in vitro activity against Ambler class A, C, and D β-lactamases.
PC-26668	GM47-1 MmpL3 inhibitor	GM47-1 is small molecule inhibitor targeting MmpL3 in Mycobacterium abscessus, has MIC50 of 1.6 uM and trigger a dose-dependent ATP increase with EC50 of 3 uM in Mycobacterium abscessus.
PC-26667	MSU-156 MmpL3 inhibitor	MSU-156 is small molecule inhibitor targeting MmpL3 in Mycobacterium abscessus, has MIC50 of 0.18 uM and trigger a dose-dependent ATP increase with in Mycobacterium abscessus.
PC-26666	MSU-155 MmpL3 inhibitor	MSU-155 is small molecule inhibitor targeting MmpL3 in Mycobacterium abscessus, has MIC50 of 0.21 uM and trigger a dose-dependent ATP increase with in Mycobacterium abscessus.
PC-26647	PAβN dihydrochloride Efflux pump inhibitor	PAβN dihydrochloride (MC-207,110) is a potent efflux pump inhibitor that potentiates effect of the activity of levofloxacin against both laboratory strains with multiple target mutations and recent clinical isolates of P. aeruginosa.
PC-26646	MBX-2319 Efflux pump inhibitor	MBX-2319 (MBX2319) is a small molecule inhibitor of AcrAB efflux pump of Escherichia coli, enhance the activity of ciprofloxacin, levofloxacin, and piperacillin in Escherichia coli.
PC-26645	TXA09155 Efflux pump inhibitor	TXA09155 is a small molecule efflux pump inhibitor, shows synergistic effect with levofloxacin against multidrug resistant P. aeruginosa clinical isolates, shows ≥8-fold potentiation of levofloxacin, moxifloxacin, doxycycline, minocycline, cefpirome, chloramphenicol, and cotrimoxazole at 6.25 ug/mL.

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