| Cat. No. |
Product Name |
Information |
| PC-25764 |
JT71
MrkH inhibitor
|
JT71 is a potent, specific small molecule inhibitor of MrkH activity, reduceds transcription of the type 3 fimbriae mrk operon, reduces K. pneumoniae mrkA promoter activity and biofilm formation. |
| PC-25751 |
ARM-1
Mfd inhibitor
|
ARM-1 (Anti-resistance molecule 1) is a specific small molecule inhibitor of bacterial RNA polymerase (RNAP)-associated DNA translocase Mfd with MST Kd of 4.25 uM, inhibits the evolution of antibiotic resistance. |
| PC-25701 |
ACX-801
PolC inhibitor
|
ACX-801 is a potent specific antibiotic for Gram-positive priority pathogens targeting the PolC DNA polymerase (IC50=5.8 uM, E. faecium PolC), demonstrates potent activity against drug-resistant priority pathogens (VRE, MRSA and PRSP), with no activity against Gram-negative bacterium E. coli. |
| PC-25700 |
Amikacin disulfate
Antibiotic
|
Amikacin (BAY 41-6551) disulfate is an aminoglycoside antibiotic that is active against most Gram-negative bacteria, including gentamicin- and tobramycin-resistant strains (E. coli, MIC=512 ug/mL), induces thioredoxin-interacting protein (TXNIP) up-regulation and suppresses migration and invasion in MDA-MB-231 cells. |
| PC-25699 |
Amikacin
Antibiotic
|
Amikacin (BAY 41-6551) is an aminoglycoside antibiotic that is active against most Gram-negative bacteria, including gentamicin- and tobramycin-resistant strains (E. coli, MIC=512 ug/mL), induces thioredoxin-interacting protein (TXNIP) up-regulation and suppresses migration and invasion in MDA-MB-231 cells. |
| PC-25654 |
JH-LPH-107
LpxH inhibitor
|
JH-LPH-107 is a highly potent LpxH inhibitor with Ki of 0.05 nM, and IC50 of 0.13 nM (K. pneumoniae LpxH), shows antibiotic activity with MIC of 0.04 ug/mL for K. pneumoniae 10031. |
| PC-25653 |
JH-LPH-106
LpxH inhibitor
|
JH-LPH-106 is a highly potent LpxH inhibitor with Ki of 0.02 nM, and IC50 of 0.044 nM (K. pneumoniae LpxH), shows antibiotic activity with MIC of 0.04 ug/mL for K. pneumoniae 10031. |
| PC-25652 |
JH-LPH-50
LpxH inhibitor
|
JH-LPH-50 is a highly potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor with Ki of 3.1 nM, and IC50 of 7.7 nM (K. pneumoniae LpxH), shows antibiotic activity with MIC of 3.3 ug/mL for wild-type K. pneumoniae (ATCC 10031). |
| PC-25651 |
JH-LPH-28
LpxH inhibitor
|
JH-LPH-28 is a highly potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor with IC50 of 110 nM and 83 nM for K. pneumoniae LpxH and E. coli LpxH respectively, shows antibiotic activity with MIC of 2.8 ug/mL for wild-type K. pneumoniae (ATCC 10031) in cell culture. |
| PC-25650 |
JH-LPH-33
LpxH inhibitor
|
JH-LPH-33 is a highly potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor with IC50 of 26 nM and 46 nM for K. pneumoniae LpxH and E. coli LpxH respectively, shows antibiotic activity with MIC of 1.6 ug/mL for wild-type K. pneumoniae (ATCC 10031) in cell culture. |
| PC-25649 |
LpxH inhibitor AZ1
LpxH inhibitor
|
LpxH inhibitor AZ1 is the first reported inhibitor of LpxH with Ki of 53.4 nM for E. coli LpxH, shows MIC of 0.25 ug/mL against E. coli MG1655 ΔtolC, AZ1 inhibits 75% of the activity of K. pneumoniae LpxH at 1 uM. |
| PC-25642 |
D-IX336
Mtb RNAP inhibitor
|
D-IX336 is a potent, selective, stereospecific activity against Mycobacterium tuberculosis RNA polymerase (Mtb RNAP) with IC50 of 1 uM, shows poor inhibition of other bacterial RNAP and human RNAP I, II, and III. |
