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Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

 
 

Cat. No. Product Name Information
PC-23552

(R)-ZG197

SaClpP agonist

(R)-ZG197 is a highly selective S. aureus caseinolytic protease P (SaClpP) activator / agonist with EC50 of 1.5 uM and Kd of 58 nM in BLI assays, 20-fold higher activity than that activates HsClpP.
PC-23551

ZG297

SaClpP agonist

ZG297 is a potent, selective S. aureus caseinolytic protease P (SaClpP) agonist with EC50 of 0.26 uM, without activity against Homo sapiens ClpP (HsClpP) (IC50>100 uM), exerts SaClpP-dependent antistaphylococcal activity.
PC-23524

REP8839

MetRS inhibitor

REP8839 (Bederocin) is a potent inhibitor of S. aureus methionyl-tRNA synthetase (MetRS) with IC50 of <1.9 nM.
PC-23523

DDD806905

MetRS inhibitor

DDD806905 is a highly potent, selective inhibitor of Leishmania donovani methionyl-tRNA synthetase (LdMetRS) with Ki of 18 nM.
PC-23456

Bedaquiline

Mycobacterial ATP synthase inhibitor

Bedaquiline fumarate (TMC207, R207910) is a diarylquinoline antibiotic that targets ATP synthase, inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit.
PC-23455

SQ31f

Mycobacterial ATP synthase inhibitor

SQ31f is a potent non-tuberculous mycobacteria antibiotic by specifically targeting the mycobacterial F-ATP synthase, inhibits ATP hydrolysis with IC50 of 0.6 uM.
PC-23291

BTI (BrpT Inhibitor)

BrpT Inhibitor

BTI (BrpT Inhibitor) is a specific small molecule inhibitor of V. vulnificus transcriptional regulator BrpT with EC50 of 6.48 uM, without affecting bacterial growth or host cell viability.
PC-23266

CBR-5992

Mtb NDH-2 inhibitor

CBR-5992 is a small molecule of Mtb type II NADH dehydrogenase (NDH-2)) inhibitor with ATP IC50 of 2.2 ug/mL, shows MIC90 of 0.5 ug/ mL against Mtb H37Rv.
PC-23224

Iclaprim

DHFR inhibitor

Iclaprim (AR-100) is a selective dihydrofolate reductase (DHFR) inhibitor, is active against methicillin, TMP and vancomycin resistant strains, has MIC90 of 0.5 ug/mL against C. trachomatis and C. pneumoniae.
PC-23214

IITR07865

MreB inhibitor

IITR07865 is a small molecule bactericidal compound that targets the MreB protein of the rod complex, induces oxidative stress in E. coli cells, exhibits growth inhibitory activity against a broad spectrum of Gram-negative rod-shaped bacteria, with MIC of 4-16 μg/mL for E. coli strains.
PC-23207

GSK138

InhA inhibitor

GSK138 (GSK3081138A) is a potent, direct inhibitor of M. tuberculosis InhA with IC50 of 0.04 uM, and MIC of 1 uM against M. tuberculosis H37Rv.
PC-23201

LPC-011

LpxC inhibitor

LPC-011 is a small-molecule LpxC inhibitor with Ki of 39 nM.

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