Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-26671	Funobactam β-lactamase inhibitor	Funobactam (XNW4107) is a novel β-lactamase inhibitor that possesses broad activity against serine-β-lactamases, displays in vitro activity against Ambler class A, C, and D β-lactamases.
PC-26668	GM47-1 MmpL3 inhibitor	GM47-1 is small molecule inhibitor targeting MmpL3 in Mycobacterium abscessus, has MIC50 of 1.6 uM and trigger a dose-dependent ATP increase with EC50 of 3 uM in Mycobacterium abscessus.
PC-26667	MSU-156 MmpL3 inhibitor	MSU-156 is small molecule inhibitor targeting MmpL3 in Mycobacterium abscessus, has MIC50 of 0.18 uM and trigger a dose-dependent ATP increase with in Mycobacterium abscessus.
PC-26666	MSU-155 MmpL3 inhibitor	MSU-155 is small molecule inhibitor targeting MmpL3 in Mycobacterium abscessus, has MIC50 of 0.21 uM and trigger a dose-dependent ATP increase with in Mycobacterium abscessus.
PC-26647	PAβN dihydrochloride Efflux pump inhibitor	PAβN dihydrochloride (MC-207,110) is a potent efflux pump inhibitor that potentiates effect of the activity of levofloxacin against both laboratory strains with multiple target mutations and recent clinical isolates of P. aeruginosa.
PC-26646	MBX-2319 Efflux pump inhibitor	MBX-2319 (MBX2319) is a small molecule inhibitor of AcrAB efflux pump of Escherichia coli, enhance the activity of ciprofloxacin, levofloxacin, and piperacillin in Escherichia coli.
PC-26645	TXA09155 Efflux pump inhibitor	TXA09155 is a small molecule efflux pump inhibitor, shows synergistic effect with levofloxacin against multidrug resistant P. aeruginosa clinical isolates, shows ≥8-fold potentiation of levofloxacin, moxifloxacin, doxycycline, minocycline, cefpirome, chloramphenicol, and cotrimoxazole at 6.25 ug/mL.
PC-26644	TXA01182 Efflux pump inhibitor	TXA01182 is a small molecule efflux pump inhibitor, shows synergistic effect with levofloxacin against several multidrug resistant P. aeruginosa clinical isolates.
PC-26643	TXA11114 Efflux pump inhibitor	TXA11114 is a small-molecule efflux pump inhibitor capable of restoring the activity of the fluoroquinolone levofloxacin against MDR P. aeruginosa.
PC-26628	Chlorhexidine Antibiotic	Chlorhexidine is an orally active cationic antimicrobial agent that targets microbial cell membranes, binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents, shows broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria.
PC-26614	NSC 156565 Pycsar inhibitor	NSC 156565 is a specific small molecule inhibitor of bacterial Pycsar immune system, selectively suppresses the Pycsar-mediated antiphage defense by targeting the cytotoxic effects of the transmembrane effector PycTM.
PC-26607	VNRX-14079 N. gonorrhoeae PBP2 inhibitor	VNRX-14079 is a specific Neisseria gonorrhoeae penicillin-binding protein (PBP2) inhibitor with IC50 of 1.7 uM for N. gonorrhoeae FA19 strain, exhibits potent antibacterial activity against multidrug-resistant N. gonorrhoeae through high-affinity binding to the PBP2.

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