| Cat. No. |
Product Name |
Information |
| PC-24883 |
HC2210
Mtb inhibitor
|
HC2210 is a novel orally bioavailable small molecule Mycobacterium tuberculosis (Mtb) growth inhibitor with EC50 of 50 nM. |
| PC-24836 |
Isoniazid
Antibiotic
|
Isoniazid (INH) is an antibiotic with bactericidal activity, has anti-tuberculostatic activity. |
| PC-24835 |
Levofloxacin
Antibiotic
|
Levofloxacin ((-)-Ofloxacin) is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria, inhibits DNA gyrase and Topoisomerase IV. |
| PC-24834 |
Streptomycin
Antibiotic
|
Streptomycin (Agrimycin, Streptomycin A) is an effective antibiotic against M. tuberculosis, binds strongly to nucleic acids, interferes and blocks protein synthesis while permitting continued RNA and DNA synthesis. |
| PC-24832 |
TPN-0157345
MmpL3 inhibitor
|
TPN-0157345 is a small molecule inhibitor of Mycobacterium tuberculosis (M.tb) mycolic acid exporter MmpL3, targets cell wall biosynthesis, inhibits aerobically cultured M. tuberculosis H37Rv with IC90 of 3.3 uM. |
| PC-24816 |
DRILS-1398
M.tb chorismate mutase inhibitor
|
DRILS-1398 is a potent inhibitor of M.tb chorismate mutase (M.tb-CM) with IC50 of 3.0 uM, demonstrates efficacy against multi-drug resistant M.tb strains (MIC=4 ug/mL), inhibits M.tb amino acid biosynthetic pathway. |
| PC-24738 |
Tarocin B
TarO inhibitor
|
Tarocin B is a specific inhibitor of UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase (TarO) with IC50 of 0.41 uM, inhibits the first step in wall teichoic acid biosynthesis, restore β-lactam efficacy against MRSA. |
| PC-24737 |
Tarocin A
TarO inhibitor
|
Tarocin A is a specific inhibitor of UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase (TarO) with IC50 of 0.18 uM, inhibits the first step in wall teichoic acid biosynthesis, restore β-lactam efficacy against MRSA. |
| PC-24471 |
TU-514
LpxC inhibitor
|
TU-514 is a substrate-analog inhibitor of zinc-dependent UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) with Ki of 3.9 uM for E. coli LpxC and IC50 of 7.0 uM (A. aeolicus LpxC) |
| PC-24470 |
L-573655
LpxC inhibitor
|
L-573655 (L-573,655) is a specific small molecule inhibitor of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC), inhibits E. coli LpxC with Ki values of 24 uM and approximately 50 nM, respectively. |
| PC-24466 |
JSF-4536
M.tb MenG inhibitor
|
JSF-4536 is a small molecule inhibitor of Mycobacterium tuberculosis methyltransferase MenG enzyme, inhibits menaquinone biosynthetic pathway, inhibits M. tuberculosis H37Rv strain with MIC of 0.78 uM. |
| PC-24465 |
JSF-4898
M.tb MenG inhibitor
|
JSF-4898 is a small molecule inhibitor of Mycobacterium tuberculosis methyltransferase MenG enzyme, inhibits menaquinone biosynthetic pathway, inhibits M. tuberculosis H37Rv strain with MIC of 0.78 uM. |
