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FG-2101

Chemical Structure : FG-2101

CAS No.: 2919723-66-1

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FG-2101 (FG2101)

Catalog No.: PC-24393Not For Human Use, Lab Use Only.

FG-2101 (FG2101) is a potent, in vivo active, non-hydroxamate inhibitor of LpxC with IC50 of 1 nM, exhibits exquisite selectivity over other bacterial and human metalloenzymes (>10,000-fold).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

FG-2101 (FG2101) is a potent, in vivo active, non-hydroxamate inhibitor of LpxC with IC50 of 1 nM, exhibits exquisite selectivity over other bacterial and human metalloenzymes (>10,000-fold).
FG-2101 exhibits potent activity against most Enterobacterales, including Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterobacter, Citrobacter, Salmonella, Shigella, and Campylobacter spp., along with biothreat pathogens Francisella tularensis and Yersinia pestis.
FG-2101 is efficacious in multiple animal models of Gram-negative infection including drug-resistant strains via IV and oral routes of administration, does not display preclinical toxicity observed with previous hydroxamate-based inhibitors.

Physicochemical Properties

M.Wt 589.59
Formula C30H32N5O6P
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-Azetidinecarbonitrile, 1-[(2S)-3-[1,6-dihydro-6-oxo-5-(phosphonooxy)-4-pyrimidinyl]-2-[4-[2-[4-(4-morpholinylmethyl)phenyl]ethynyl]phenyl]propyl]-

References

1. Patent WO2023055686 A1.

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