Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-23309	MRS-2541 MetRS inhibitor	MRS-2541 a novel potent inhibitor of methionyl-tRNA synthetase (MetRS) with selective activity against gram-positive bacteria with MIC of 0.063-0.5 ug/mL against Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus species.
PC-23291	BTI (BrpT Inhibitor) BrpT Inhibitor	BTI (BrpT Inhibitor) is a specific small molecule inhibitor of V. vulnificus transcriptional regulator BrpT with EC50 of 6.48 uM, without affecting bacterial growth or host cell viability.
PC-23266	CBR-5992 Mtb NDH-2 inhibitor	CBR-5992 is a small molecule of Mtb type II NADH dehydrogenase (NDH-2)) inhibitor with ATP IC50 of 2.2 ug/mL, shows MIC90 of 0.5 ug/ mL against Mtb H37Rv.
PC-23241	Zidebactam β-lactam enhancer	Zidebactam (WCK-5107) is a β-Lactam Enhancer, inhibitor of class A, class C and some class D β-lactamases with MIC of <2 ug/ mL for most Escherichia coli , Klebsiella , Citrobacter and Enterobacter spp., also binds to penicillin-binding protein2 (PBP2).
PC-23224	Iclaprim DHFR inhibitor	Iclaprim (AR-100) is a selective dihydrofolate reductase (DHFR) inhibitor, is active against methicillin, TMP and vancomycin resistant strains, has MIC90 of 0.5 ug/mL against C. trachomatis and C. pneumoniae.
PC-23214	IITR07865 MreB inhibitor	IITR07865 is a small molecule bactericidal compound that targets the MreB protein of the rod complex, induces oxidative stress in E. coli cells, exhibits growth inhibitory activity against a broad spectrum of Gram-negative rod-shaped bacteria, with MIC of 4-16 μg/mL for E. coli strains.
PC-23207	GSK138 InhA inhibitor	GSK138 (GSK3081138A) is a potent, direct inhibitor of M. tuberculosis InhA with IC50 of 0.04 uM, and MIC of 1 uM against M. tuberculosis H37Rv.
PC-23202	CHIR-090 LpxC inhibitor	CHIR-090 is a potent, slow, tight-binding inhibitor of the LpxC deacetylase, binds to E. coli LpxC with Ki of 4.0 nM, displays good antimicrobial activity against several Gram-negative bacteria.
PC-23201	LPC-011 LpxC inhibitor	LPC-011 is a small-molecule LpxC inhibitor with Ki of 39 nM.
PC-23182	Taniborbactam hydrochloride Beta-lactamase inhibitor	Taniborbactam (VNRX5133) hydrochloride is a highly potent and specific beta-lactamase inhibitor with IC50 of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2 respectively.
PC-23181	BFstatin BrpR inhibitor	BFstatin (175C05) is a small molecule inhibitor of V. vulnificus BrpR with EC50 of 8.01 uM, a transcriptional regulator for biofilm genes.
PC-23145	SPR741 Antibiotic adjuvant	SPR741 (NAB741) is a cationic peptide derived from polymyxin B and antibiotic adjuvant, increases the permeability of the outer membrane of Gram-negative bacteria.

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