Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-42559	Sutezolid Anti-tuberculosis agent	Sutezolid (PNU-100480, PF-02341272) is an oxazolidinone antibiotic that possesses potent antituberculosis activity in vitro and in vivo, by inhibiting bacterial protein synthesis.
PC-42560	Eperezolid Antibacterial	Eperezolid (PNU-100592) is an oxazolidinone antibiotic that possesses potent antimicrobial activity in vitro and in vivo, binds specifically to the 50S ribosomal subunit of Escherichia coli.
PC-42178	Lenampicillin hydrochloride Beta-lactam antibiotic	Lenampicillin hydrochloride (KBT1585) is an efficient prodrug of ampicillin with enhanced absorption and decreased side effects, inhibits bacterial penicillin-binding proteins (transpeptidase), an effective beta-lactam antibacterial agent.
PC-47423	Norvancomycin hydrochloride Antibiotic	Norvancomycin hydrochloride (Desmethyl-vancomycin hydrochloride) is an antibiotic used to treat a number of bacterial infections that acts by inhibiting proper cell wall synthesis.
PC-46819	Vancomycin Antibiotic	Vancomycin is an antibiotic used to treat a number of bacterial infections that acts by inhibiting proper cell wall synthesis.
PC-45586	Anisomycin	Anisomycin (Flagecidin, Wuningmeisu C) is an antibiotic that inhibits eukaryotic protein synthesis by inhibiting peptidyl transferase or the 80S ribosome.
PC-42061	Tubercidin Antibiotic	Tubercidin (7-Deazaadenosine) is an antibiotic and adenosine analog isolated from the bacterium Streptomyces tubercidicus with potential antineoplastic activity.
PC-45750	Vaborbactam serine β-lactamase inhibitor	Vaborbactam (RPX-7009) is a serine β-lactamase inhibitor that notably restores the activity of carbapenems against KPC-producing strains.
PC-45277	Garenoxacin mesylate hydrate Antibiotic	Garenoxacin mesylate hydrate (BMS284756) is a quinolone antibiotic for the treatment of Gram-positive and Gram-negative bacterial infections.
PC-45276	Garenoxacin Antibiotic	Garenoxacin (BMS284756) is a quinolone antibiotic for the treatment of Gram-positive and Gram-negative bacterial infections.
PC-42192	DprE1-IN-25 DprE1 inhibitor	DprE1-IN-25 is a potent, noncovalent DprE1 inhibitor with IC50 of 43 nM, shows activity against Mycobacterium tuberculosis (Mtb) in vitro with MIC of 0.39 uM.
PC-45087	AFN-1252 FabI inhibitor	AFN-1252 (API-1252, Debio 1452) is a potent inhibitor of bacterial enoyl-ACP reductase FabI.

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