Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-42302	Q203 Mtb QcrB inhibitor	Telacebec (Q203, IAP6) is a novel potent anti-tuberculosis agent targeting cytochrome b subunit qcrB, inhibits M. tuberculosis H37Rv with MIC50 of of 2.7 nM.
PC-45436	Walrycin B Baterial WalR regulator, 3CLpro inhibitor	Walrycin B is a baterial WalR response regulator, an analogue of toxoflavin and a potent SARS-CoV-2 3CLpro inhibitor with IC50 of 0.26 uM.
PC-42236	BM212 MmpL3 inhibitor	BM212 is a novel antitubercular agent that possesses strong inhibitory activity against both Mycobacterium tuberculosis (MIC=0.7-1.5 ug/ml) and some nontuberculosis mycobacteria, inhibits transport activity of MmpL3.
PC-45367	Fidaxomicin Antibiotic	Fidaxomicin (OPT-80, PAR-101) is a new class of narrow spectrum macrocyclic antibiotic drug and RNA polymerase inhibitor, shows potent anti-Clostridium difficile activity with MIC90 of 0.12 ug/mL.
PC-42715	Delamanid	Delamanid (OPC-67683) is a mycolic acid biosynthesis inhibitor found to be free of mutagenicity and to possess highly potent activity against tuberculosis, including MDR-TB.
PC-45263	Azathramycin Antibiotic	Azathramycin is a macrolide antibiotic that effectively inhibits tumor angiogenesis by suppressing VEGFR2-mediated signaling pathways in lung cancer.
PC-45638	Ribocil-C FMN riboswitch inhibitor	Ribocil-C is a highly selective inhibitor of the FMN riboswitch that controls expression of de novo riboflavin (Vitamin B2) biosynthesis in Escherichia coli.
PC-42665	Gatifloxacin Bacterial DNA gyrase inhibitor	Gatifloxacin (PD 135432, AM1155) is a fourth-generation fluoroquinolone antibiotic that inhibits the bacterial DNA gyrase and topoisomerase IV.
PC-42048	Faropenem daloxate Beta-lactam antibiotic	Faropenem daloxate (Faropenem medoxil) is a daloxate ester prodrug of Faropenem with broad-spectrum antibacterial activity against many gram-positive and gram-negative aerobes and anaerobes, a beta-lactam antibiotic.
PC-42714	PA-824 Antibiotic	Pretomanid (PA-824) is an anti-tuberculosis agent that inhibits the synthesis of protein and cell wall lipid.
PC-24346	NCBP1 Antibacterial	NCBP1 is a plant-derived, 11 amino acid, noncanonical antibacterial peptide with dual activity against multidrug-resistant bacterial and fungal pathogens, by targeting phosphatidylglycerol and cardiolipin in bacterial membrane, resulting in membrane damage and dysfunction.
PC-24340	DNA gyrase inhibitor 35 2088347-91-3	DNA gyrase inhibitor 35 is potent small molecule DNA gyrase inhibitor with IC50 of 1.2 μM of E.coli DNA gyrase, also shows low micromolar inhibition of E. coli topoisomerase IV and of the respective Staphylococcus aureus homologues.

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