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Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

 
 

Cat. No. Product Name Information
PC-42715

Delamanid

Delamanid (OPC-67683) is a mycolic acid biosynthesis inhibitor found to be free of mutagenicity and to possess highly potent activity against tuberculosis, including MDR-TB.
PC-45263

Azathramycin

Antibiotic

Azathramycin is a macrolide antibiotic that effectively inhibits tumor angiogenesis by suppressing VEGFR2-mediated signaling pathways in lung cancer.
PC-45638

Ribocil-C

FMN riboswitch inhibitor

Ribocil-C is a highly selective inhibitor of the FMN riboswitch that controls expression of de novo riboflavin (Vitamin B2) biosynthesis in Escherichia coli.
PC-42665

Gatifloxacin

Bacterial DNA gyrase inhibitor

Gatifloxacin (PD 135432, AM1155) is a fourth-generation fluoroquinolone antibiotic that inhibits the bacterial DNA gyrase and topoisomerase IV.
PC-42048

Faropenem daloxate

Beta-lactam antibiotic

Faropenem daloxate (Faropenem medoxil) is a daloxate ester prodrug of Faropenem with broad-spectrum antibacterial activity against many gram-positive and gram-negative aerobes and anaerobes, a beta-lactam antibiotic.
PC-42714

PA-824

Antibiotic

Pretomanid (PA-824) is an anti-tuberculosis agent that inhibits the synthesis of protein and cell wall lipid.
PC-23766

MtbFadD32 inhibitor M1

Mtb FadD32 inhibitor

MtbFadD32 inhibitor M1 is a small molecule inhibitor of Mycobacterium tuberculosis fatty acyl-AMP ligase FadD32 and FadD28, shows specific antitubercular activity with IC50 of 4.8 ug/mL, binds and inhibits the FAAL activity of MtbFadD32 and MtbFadD28 enzymes.
PC-23757

STK848198

FtsH inhibitor

STK848198 is a small molecule antimicrobial compound with MIC of 2 ug/mL against S. aureus by targeting ATP‐binding protein FtsH, inhibits methicillin‐sensitive S. aureus, MSRA, VAN intermediate S. aureus (VISA), and DAP‐resistant strains with MIC ranged from 0.5 to 8 ug/mL.
PC-23656

Evybactin

M.tb DNA gyrase inhibitor

Evybactin is a potent and selective antibiotic acting against M. tuberculosis (MIC=0.25 ug/mL) targeting DNA gyrase.
PC-23591

Miltefosine

58066-85-6

Miltefosine is a phosphatidylcholine analog with anti-leishmanial activity, inhibits PI3K/Akt activity, shows broad spectrum antimicrobial, anti-leishmanial and anticoronaviral activity.
PC-23552

(R)-ZG197

SaClpP agonist

(R)-ZG197 is a highly selective S. aureus caseinolytic protease P (SaClpP) activator / agonist with EC50 of 1.5 uM and Kd of 58 nM in BLI assays, 20-fold higher activity than that activates HsClpP.
PC-23551

ZG297

SaClpP agonist

ZG297 is a potent, selective S. aureus caseinolytic protease P (SaClpP) agonist with EC50 of 0.26 uM, without activity against Homo sapiens ClpP (HsClpP) (IC50>100 uM), exerts SaClpP-dependent antistaphylococcal activity.

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