| Cat. No. |
Product Name |
Information |
| PC-22472 |
BTZ043
DprE1 inhibitor
|
BTZ043 (BTZ-043) is a small molecule antimycobacterial agent taregting the DprE1 (Rv3790) subunit of the enzyme decaprenylphosphoryl-beta-d-ribose 2'-epimerase, shows MIC values of 1 ng/ml (2.3 nM) and 4 ng/ml (9.2 nM) against M. tuberculosis H37Rv and Mycobacterium smegmatis, respectively. |
| PC-22468 |
Lolamicin
LolCDE inhibitor
|
Lolamicin is a Gram-negative-specific antibiotic targeting the lipoprotein transport system LolCDE complex, shows potent activity in against Gram-negative pathogens, sparing the gut microbiome. |
| PC-22410 |
Lefamulin
Antibiotic
|
Lefamulin (BC-3781) is a pleuromutilin class of antimicrobial agent, inhibits bacterial protein synthesis by selectively binding to the peptidyl transferase center of the bacterial ribosome, prevents the correct positioning of the 3′-CCA ends of tRNAs for peptide transfer. |
| PC-22409 |
Lefamulin acetate
Antibiotic
|
Lefamulin (BC-3781) acetate is a pleuromutilin class of antimicrobial agent, inhibits bacterial protein synthesis by selectively binding to the peptidyl transferase center of the bacterial ribosome, prevents the correct positioning of the 3′-CCA ends of tRNAs for peptide transfer. |
| PC-22350 |
Cadazolid
Antibiotic
|
Cadazolid (ACT-179811) is a first-in-class quinoxolidinone antibiotic and a potent inhibitor of C. difficile protein synthesis with IC50 of 0.38 uM in in vitro transcription/translation assay, MIC of <0.03 ug/mL against Clostridioides difficile ATCC 700057. |
| PC-22142 |
Mupirocin
FTO inhibitor, Antibiotic
|
Mupirocin (BRL-4910A, Pseudomonic acid) is an orally active antibiotic isolated from Pseudomonas fluorescens, reversibly inhibits isoleucyl-transfer RNA and bacterial protein/RNA synthesis, also is an inhibitor of m6A demethylase fat mass and obesity-associated protein (FTO), induces CRC ferroptosis and inhibits tumor growth. |
| PC-22131 |
Irresistin-16
DHFR inhibitor
|
Irresistin-16 (IRS-16) is a potent bacterial dihydrofolate reductase (DHFR) inhibitor for purified E. coli DHFR (FolA), exhibits potent activity against S.aureus MRSA and N. gonorrhoeae with MIC of 1.56 and 0.03 ug/mL, respectively. |
| PC-22101 |
IITR08367
Efflux pump AbaF inhibitor
|
IITR08367 is a potent efflux inhibitor against AbaF in A. baumannii, inhibits efflux pumps by disrupting the proton gradient across the bacterial membrane. |
| PC-22091 |
EBL-3599
LpxH inhibitor
|
EBL-3599 is a novel LpxH inhibitor with IC50 of 3.5 nM for E. coli LpxH enzyme, shows potent activity targeting lipopolysaccharide synthesis in Gram-negative bacteria (K. pneumoniae ATCC 13883, MIC 1 mg/mL). |
| PC-21953 |
Zosurabalpin
Antibiotic
|
Zosurabalpin (Abx MCP, RG6006) is a small-molecule, tethered macrocyclic peptide antibiotic targeting the lipopolysaccharide (LPS) transporter, has MIC of 0.06 ug/mL A. baumannii ATCC 17978. |
| PC-21689 |
BDM91288
AcrB efflux pump inhibitor
|
BDM91288 is a pyridylpiperazine-based AcrB efflux pump inhibitor, potentiates the activity of a panel of antibiotics against K. pneumoniae. |
| PC-21661 |
TBAJ-5307
Non-tuberculous mycobacteria inhibitor
|
TBAJ-5307 is a broad spectrum anti-non-tuberculous mycobacteria (NTM) inhibitor targeting FO-domain of F1FO-ATP synthase, shows MIC50 of 4.5 nM and 6 nM against the Mab subsp. abscessus smooth strain and rough strain respectively. |
