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Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

 
 

Cat. No. Product Name Information
PC-61388

Macozinone

Macozinone (PBTZ-169, PBTZ169) is a potent, second-generation antituberculosis agent that inhibits DprE1 and displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.
PC-61371

Contezolid

Contezolid (MRX I) is an orally active oxazolidinone agent with antibacterial activity Gram-positive pathogens, including MRSA, penicillin-PRSP, PISP, and vancomycin-resistant enterococci (VRE) with MIC of 0.25-4 ug/mL.
PC-61295

Murepavadin

Antibiotic, MRGPRX2 agonist

Murepavadin (POL7080) is a highly potent, specific, macrocycle Pseudomonas antibiotic, activates mast cells via MRGPRX2 and MrgprB2.
PC-61266

KKL-40

A small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture.
PC-61265

KKL-10

KKL-10 is a small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture.
PC-70341

DSM 74

Pf DHODH inhibitor

DSM 74 is a potent, orally active PfDHODH inhibitor (IC50=0.3 uM) with antimalarial activity.
PC-70340

Genz 669178

Pf DHODH inhibitor

Genz 669178 is a potent PfDHODH inhibitor that exhibits low nanomolar in vitro potency against DHODH from P falciparum, P vivax, and P berghei.
PC-70339

IDI-6273

Pf DHODH inhibitor

IDI-6273 is a potent, mutant-selective PfDHODH inhibitor with IC50 of 210 nM for 3D7 E182D PfDHODH.
PC-60900

M4284

M4284 (M-4284) is a high-affinity biphenyl mannoside FimH inhibitor with HAI of 16 nM in hemagglutination assay.
PC-70093

Roseoflavin

Antibiotic

Roseoflavin is a chemical analog of FMN and riboflavin that has antimicrobial activity.
PC-60091

GSK-656

Mtb LeuRS inhibitor

GSK-656 (Ganfeborole; GSK-3036656, GSK656) is a potent, highly selective,orally bioavailable Mtb Leucyl-tRNA synthetase (LeuRS) with IC50 of 0.2 uM.
PC-45637

Ribocil

FMN riboswitch inhibitor

Ribocil is a synthetic mimic of riboflavin 5’-monophosphate (FMN) that competes with the natural ligand to inhibit FMN riboswitch-mediated expression of ribB.

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