| Cat. No. |
Product Name |
Information |
| PC-38633 |
GSK2556286
M.tb inhibitor
|
GSK2556286 (GSK286) a novel inhibitor of M. tuberculosis extracellularly in the presence of cholesterol and within human macrophages, inhibits growth within human macrophages with IC50 of 70 nM (H37Rv in THP-1 cells). |
| PC-38560 |
DU011
MprA inhibitor
|
DU011 is a noncanonical anti-infective agent and small-molecule inhibitor of capsule biogenesis, targets MprA (Kd=30 nM), a MarR family transcriptional repressor of multidrug efflux pumps, inhibits capsule expression in E. coli. |
| PC-38554 |
PKZ18-22
Antibiotic
|
PKZ18-22 is a potency improved analog of PKZ18, inhibitiong tRNA-regulated gene expression of gram-positive bacteria, shows MIC value of 8 ug/mL against S. aureus. |
| PC-38553 |
PKZ18
Antibiotic
|
PKZ18 is a small-molecule antibiotic inhibiting the in vivo transcription of glycyl-tRNA synthetase mRNA in gram-positive bacteria, aslo inhibits in vivo translation of the S. aureus threonyl-tRNA synthetase protein. |
| PC-38471 |
GW779439X
PASTA kinase Stk1 inhibitor
|
GW779439X is a small-molecule kinase inhibitor that sensitizes methicillin-resistant Staphylococcus aureus (MRSA) to β-lactam antibiotics via inhibition of the PASTA kinase Stk1. |
| PC-38420 |
LpxC-IN-5
LpxC inhibitor
|
LpxC-IN-5 is a potent non-hydroxamate LpxC (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor with IC50 of 20 nM, shows antibacterial activity against E. coli ATCC25922, P. aeruginosa ATCC27853, K. pneumoniae ATCC13883 and P. aeruginosa 5567 with MIC of 16, 4, 64, and 4 ug/mL, respectively. |
| PC-38406 |
QZN 34
PqsR inhibitor
|
QZN 34 is a small molecule pseudomonas aeruginosa PQS quorum-sensing system (PqsR) inhibitor with IC50 of 15 uM, kills planktonic Gram-positives (S. aureus, MIC 6.25 uM) but not Gram-negatives. |
| PC-38403 |
Morponidazole
Antibiotic
|
Morponidazole is a nitroimidazoles antibiotic for bacterial infections. |
| PC-38364 |
DNV3837
C. difficile inhibitor
|
MCB 3681 is a quinolonyl-oxazolidinone bactericidal antibiotic, has activity in vitro against Gram-positive bacteria. MCB3681 has a potent in vitro activity against C. difficile with MIC90 of 0.064 ug/ml. |
| PC-38363 |
LFF-571
Bactericidal antibiotic
|
LFF571 is a semisynthetic thiopeptide and bactericidal antibiotic that interferes with bacterial protein synthesis by inhibition of elongation factor EF-Tu, LFF571 is potent in vitro activity against C.difficile strains with MIC90 of 0.25 ug/mL. |
| PC-38362 |
MGB-BP-3
C. difficile inhibitor
|
MGB-BP-3 is a potent bactericidal antibiotic with a completely novel mode of action, selectively binds to the minor grove of microbial DNA, has the potential for Clostridioides difficile infection (CDI). |
| PC-38361 |
Ibezapolstat
DNA pol IIIC inhibitor
|
Ibezapolstat (ACX-362E) is a potent, selective, first-in-class DNA polymerase IIIC (DNA pol IIIC) inhibitor with IC50 of 51 nM (B. Subtilis pol IIIC), inhibits C. difficile efficiently (MIC50, 2 ug/mL). |
