Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-20585	MAC13243 LolA inhibitor	MAC13243 is a small molecule inhibitor of the bacterial lipoprotein targeting chaperone LolA (Kd=7.5 uM), exhibits potent Gram-negative antibacterial activity with MIC value of 4 ug/mL (Pseudomonas aeruginosa PA01).
PC-20571	IMP-1700 Bacterial AddAB complex inhibitor	IMP-1700 (IMP1700) is a potent, cell-active inhibitor of bacterial AddAB-mediated DNA repair, sensitizes MRSA to ciprofloxacin (CFX) with an EC50 of 5.9 nM.
PC-72742	Irloxacin Antibacterial agent	Irloxacin (Pirfloxacin) is a fluorinated quinolone derivative, is an antibacterial agent with proved activity against both gram-positive and gram-negative bacteria.
PC-72489	LolCDE inhibitor compound 2A LolCDE inhibitor	LolCDE inhibitor compound 2A is a small molecule inhibitor that inhibits the growth of P. aeruginosa by interfering with the function of the lipoprotein transport components LolCDE complex.
PC-72418	COR588 Lysine-gingipain inhibitor	COR588 is a second-generation small-molecule lysine-gingipain (Kgp) inhibitor.
PC-45375	Penicillin G potassium	An antibiotic used to treat a number of bacterial infections..
PC-45181	Vancomycin hydrochloride	An antibiotic used to treat a number of bacterial infections that acts by inhibiting proper cell wall synthesis..
PC-45312	Clarithromycin	An antibiotic by acting as a protein synthesis inhibitor.
PC-42061	Tubercidin	An antibiotic and adenosine analog isolated from the bacterium Streptomyces tubercidicus with potential antineoplastic activity.
PC-45392	Framycetin	An aminoglycoside antibiotic.
PC-45349	Apramycin	An aminoglycoside antibiotic used in veterinary medicine..
PC-45352	G-418 disulfate	An aminoglycoside antibiotic similar in structure to gentamicin B1.

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