Chemical Structure : LPC-058
CAS No.:
1363368-18-6
LPC-058
(LPC058)
Catalog No.: PC-25324Not For Human Use, Lab Use Only.
LPC-058 is a potent inhibitor of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC), displays broad-spectrum antibiotic activity against antibiotic resistant Gram-negative pathogens.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LPC-058 is a potent inhibitor of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC), displays broad-spectrum antibiotic activity against antibiotic resistant Gram-negative pathogens.
LPC-058 has MIC90 values for Enterobacteriaceae, P. aeruginosa, Burkholderia cepacia and A. baumannii of 0.12, 0.5, 1 and 1 mg/L, respectively.
LPC-058 is bactericidal at 1× or 2× MIC against CTX-M-15, KPC-2 and VIM-1 carbapenemase-producing strains and bacteriostatic at ≤4× MIC against OXA-23 carbapenemase-producing A. baumannii.
Combinations of LPC-058 with β-lactams, amikacin and ciprofloxacin are synergistic against these strains, albeit in a species-dependent manner.
Physicochemical Properties
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M.Wt
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427.41
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Formula
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C22H19F2N3O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-[(4-Aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3S)-4,4-difluoro-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]benzamide
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References
1. Titecat M, et al. J Antimicrob Chemother. 2016 Oct;71(10):2874-82.
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