Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-45637	Ribocil FMN riboswitch inhibitor	Ribocil is a synthetic mimic of riboflavin 5’-monophosphate (FMN) that competes with the natural ligand to inhibit FMN riboswitch-mediated expression of ribB.
PC-45713	N-Acetyl-Calicheamicin	N-Acetyl-Calicheamicin is a enediyne antitumor antibiotic.
PC-45750	Vaborbactam serine β-lactamase inhibitor	Vaborbactam (RPX-7009) is a serine β-lactamase inhibitor that notably restores the activity of carbapenems against KPC-producing strains.
PC-42192	DprE1-IN-25 DprE1 inhibitor	DprE1-IN-25 is a potent, noncovalent DprE1 inhibitor with IC50 of 43 nM, shows activity against Mycobacterium tuberculosis (Mtb) in vitro with MIC of 0.39 uM.
PC-45070	Relebactam	Relebactam (MK-7655) is a novel β-lactamase inhibitor that inhibited both class A and C β-lactamases in vitro.
PC-45372	Dalbavancin Antibiotic	Dalbavancin (MDL-63397, BI-397) is a novel second-generation lipoglycopeptide antibiotic with MIC90 values of 0.06 μg/mL and 0.25 μg/mL for Staphylococcus aureus and Bacillus anthracis, respectively.
PC-42302	Q203	A novel potent anti-tuberculosis agent targeting cytochrome b subunit qcrB, inhibits M. tuberculosis H37Rv with MIC50 of of 2.7 nM.
PC-45367	Fidaxomicin	Fidaxomicin(OPT-80; PAR-101) is a new class of narrow spectrum macrocyclic antibiotic drug, selective eradication of pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria.
PC-42715	Delamanid	Delamanid (OPC-67683) is a mycolic acid biosynthesis inhibitor found to be free of mutagenicity and to possess highly potent activity against tuberculosis, including MDR-TB.
PC-45638	Ribocil-C FMN riboswitch inhibitor	Ribocil-C is a highly selective inhibitor of the FMN riboswitch that controls expression of de novo riboflavin (Vitamin B2) biosynthesis in Escherichia coli.
PC-42665	Gatifloxacin Bacterial DNA gyrase inhibitor	Gatifloxacin (PD 135432, AM1155) is a fourth-generation fluoroquinolone antibiotic that inhibits the bacterial DNA gyrase and topoisomerase IV.
PC-42714	PA-824 Antibiotic	Pretomanid (PA-824) is an anti-tuberculosis agent that inhibits the synthesis of protein and cell wall lipid.

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