Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-42715	Delamanid	Delamanid (OPC-67683) is a mycolic acid biosynthesis inhibitor found to be free of mutagenicity and to possess highly potent activity against tuberculosis, including MDR-TB.
PC-45638	Ribocil-C FMN riboswitch inhibitor	Ribocil-C is a highly selective inhibitor of the FMN riboswitch that controls expression of de novo riboflavin (Vitamin B2) biosynthesis in Escherichia coli.
PC-42665	Gatifloxacin Bacterial DNA gyrase inhibitor	Gatifloxacin (PD 135432, AM1155) is a fourth-generation fluoroquinolone antibiotic that inhibits the bacterial DNA gyrase and topoisomerase IV.
PC-42714	PA-824 Antibiotic	Pretomanid (PA-824) is an anti-tuberculosis agent that inhibits the synthesis of protein and cell wall lipid.
PC-22162	MLEB-1934 Bacterial DNA gyrase inhibitor	MLEB-1934 is a potent bacterial DNA gyrase inhibitor with MIC of 0.25 μg/mL in MRSA, targets the allosteric pocket of the gyrase.
PC-22142	Mupirocin FTO inhibitor, Antibiotic	Mupirocin (BRL-4910A, Pseudomonic acid) is an orally active antibiotic isolated from Pseudomonas fluorescens, also is an inhibitor of m6A demethylase fat mass and obesity-associated protein (FTO), induces CRC ferroptosis and inhibits tumor growth.
PC-22138	G0775 Bacterial SPase LepB inhibitor	G0775 is a novel potent, broad-spectrum antibiotic against Gram-negative bacteria (MDR K. pneumoniae CDC 0106, MIC=0.5 ug/mL), inhibits the Gram-negative type I signal peptidase (SPase) LepB with Ki of 0.44 nM, a new antibiotic target.
PC-22131	Irresistin-16 DHFR inhibitor	Irresistin-16 (IRS-16) is a potent bacterial dihydrofolate reductase (DHFR) inhibitor for purified E. coli DHFR (FolA), exhibits potent activity against S.aureus MRSA and N. gonorrhoeae with MIC of 1.56 and 0.03 ug/mL, respectively.
PC-22130	Fluorofolin DHFR inhibitor	Fluorofolin is a potent bacterial dihydrofolate reductase (DHFR) inhibitor with IC50 of 2.5 nM for purified E. coli DHFR (FolA), exhibits potent activity against P. aeruginosa PA14 with MIC of 3.1 ug/mL.
PC-22093	X20404 Mtb Pks13 inhibitor	X20404 is a small molecule inhibitor of the thioesterase activity of Mtb polyketide synthase 13 (Pks13) with IC50 of 0.4 uM in the Pks13-TE enzyme assay.
PC-22092	EBL-3647 LpxH inhibitor	EBL-3647 is a novel LpxH inhibitor with IC50 of 2.2 nM for E. coli LpxH enzyme, shows potent activity targeting lipopolysaccharide synthesis in Gram-negative bacteria (K. pneumoniae ATCC 13883, MIC 0.5 mg/mL).
PC-22091	EBL-3599 LpxH inhibitor	EBL-3599 is a novel LpxH inhibitor with IC50 of 3.5 nM for E. coli LpxH enzyme, shows potent activity targeting lipopolysaccharide synthesis in Gram-negative bacteria (K. pneumoniae ATCC 13883, MIC 1 mg/mL).

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