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Chemical Structure : Quabodepistat
Catalog No.: PC-73439Not For Human Use, Lab Use Only.
Quabodepistat (OPC-167832) is a highly potent antituberculosis agent with MIC of 0.00024 to 0.002 ug/mL against Mycobacterium tuberculosis, targets DprE1 (IC50=258 nM, recombinant DprE1), an essential enzyme for cell wall biosynthesis.
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Quabodepistat (OPC-167832) is a highly potent antituberculosis agent with MIC of 0.00024 to 0.002 ug/mL against Mycobacterium tuberculosis, targets DprE1 (IC50=258 nM, recombinant DprE1), an essential enzyme for cell wall biosynthesis.
OPC-167832 showed MIC90 of 0.0048 and 0.0027 ug/mL against intracellular M. tuberculosis strains H37Rv and Kurono were 0.0048 and 0.0027, respectively.
OPC-167832 showed potent bactericidal activities starting at a dose of 0.625 mg/kg of body weight in a mouse model of chronic TB.
OPC-167832 exhibited significant combination effects in 2-drug combinations with delamanid, bedaquiline, or levofloxacin.
| M.Wt | 456.846 | |
| Formula | C21H20ClF3N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hariguchi N, et al. Antimicrob Agents Chemother. 2020 May 21;64(6):e02020-19.
2. Robertson GT, et al. Antimicrob Agents Chemother. 2021 Oct 18;65(11):e0058321.
3. Tasneen R, et al. Antimicrob Agents Chemother. 2022 Mar 22:e0239821.
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