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Chemical Structure : LFF-571
Catalog No.: PC-38363Not For Human Use, Lab Use Only.
LFF571 is a semisynthetic thiopeptide and bactericidal antibiotic that interferes with bacterial protein synthesis by inhibition of elongation factor EF-Tu, LFF571 is potent in vitro activity against C.difficile strains with MIC90 of 0.25 ug/mL.
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LFF571 is a semisynthetic thiopeptide and bactericidal antibiotic that interferes with bacterial protein synthesis by inhibition of elongation factor EF-Tu, LFF571 is potent in vitro activity against C.difficile strains with MIC90 of 0.25 ug/mL.
LFF571 demonstrated activity against most other Gram-positive rods and cocci (MIC50/90, 0.125/0.25 μg/mL) except for bifidobacteria and some species of lactobacilli, showed reduced active activity against Gram-negative anaerobes with MICs for Bacteroides fragilis of 4 and 8 μg/mL.
LFF571 inhibits exogenous protein synthesis elongation factor EF-Tu and interferes with the ability for EF-Tu to deliver aminoacylated tRNA to the ribosome.
| M.Wt | 1366.61 | |
| Formula | C60H63N13O13S6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. LaMarche MJ, et al. J Med Chem. 2012 Mar 8;55(5):2376-87.
2. Trzasko A, et al. Antimicrob Agents Chemother. 2012 Aug;56(8):4459-62.
3. Leeds JA, et al. Antimicrob Agents Chemother. 2012 Aug;56(8):4463-5.
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