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AX20017

Chemical Structure : AX20017

CAS No.: 329221-38-7

AX20017 (AX 20017)

Catalog No.: PC-73194Not For Human Use, Lab Use Only.

AX20017 is a highly selective inhibitor of Mycobacterium tuberculosis protein kinase G (PknG) with IC50 of 0.39 uM.

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Biological Activity

AX20017 is a highly selective inhibitor of Mycobacterium tuberculosis protein kinase G (PknG) with IC50 of 0.39 uM.
AX20017 is buried deep within the adenosine-binding site, targeting an active conformation of the kinase domain.
AX20017 is a reference to determine candidate compounds that can act as potential inhibitors for PknG as anti-mycobacterium tuberculosis compounds.

Physicochemical Properties

M.Wt 268.37
Formula C13H20N2O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(Cyclopropanecarboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide

References

1. Walburger A, et al. Science. 2004 Jun 18;304(5678):1800-4.

2. Scherr N, et al. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12151-6.

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