Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-45926	Moxifloxacin Antibiotic	Moxifloxacin is a fourth-generation synthetic fluoroquinolone, broad-spectrum antibacterial agent that is active against both Gram-positive and Gram-negative bacteria; inhibits DNA gyrase and topoisomerase IV.
PC-45925	Moxifloxacin hydrochloride Antibiotic, DNA gyrase inhibitor	Moxifloxacin hydrochloride (BAY 12-8039) is a fourth-generation synthetic fluoroquinolone, broad-spectrum antibacterial agent that is active against both Gram-positive and Gram-negative bacteria, inhibits DNA gyrase and topoisomerase IV.
PC-42665	Gatifloxacin Bacterial DNA gyrase inhibitor	Gatifloxacin (PD 135432, AM1155) is a fourth-generation fluoroquinolone antibiotic that inhibits the bacterial DNA gyrase and topoisomerase IV.
PC-42048	Faropenem daloxate Beta-lactam antibiotic	Faropenem daloxate (Faropenem medoxil) is a daloxate ester prodrug of Faropenem with broad-spectrum antibacterial activity against many gram-positive and gram-negative aerobes and anaerobes, a beta-lactam antibiotic.
PC-42714	Pretomanid Mtb inhibitor	Pretomanid (PA-824) is an anti-tuberculosis agent that inhibits the synthesis of protein and cell wall lipid.
PC-28531	S. aureus ClpC activator Cpd-8 S. aureus ClpC activator	S. aureus ClpC activator Cpd-8 is a small-molecule activator of the Staphylococcus aureus ClpC/ClpP AAA+ protease with EC50 of 12 uM, binds to ClpC N-terminal domain (NTD), induces ClpC/ClpP-independent toxicity in Staphylococcus aureus.
PC-28530	S. aureus ClpC activator Cpd-10 S. aureus ClpC activator	S. aureus ClpC activator Cpd-10 is a small-molecule activator of the Staphylococcus aureus ClpC/ClpP AAA+ protease with EC50 of 4.4 uM, induces ClpC/ClpP-independent toxicity in Staphylococcus aureus
PC-28495	Kasugamycin hydrochloride Antibiotic	Kasugamycin hydrochloride (Ksg) is a small ribosomal subunit-targeting antibiotic, binds to the bacterial 30S ribosomal subunit and inhibits canonical translation initiation, possesses anti-infective activity.
PC-28494	Kasugamycin Antibiotic	Kasugamycin (Ksg) is a small ribosomal subunit-targeting antibiotic, binds to the bacterial 30S ribosomal subunit and inhibits canonical translation initiation, possesses anti-infective activity.
PC-28393	NDM-552 PBP2 inhibitor	NDM-552 is a Gram-positive selective antibacterial agent that potentially targets penicillin-binding protein 2 (PBP2)-associated cell wall biosynthesis, exhibits activity against Gram-positive pathogens including S. aureus, Enterococcus faecium, and Staphylococcus epidermidis with MIC of 1-2 ug/mL.
PC-28263	Murepavadin TFA Antibiotic, MRGPRX2 agonist	Murepavadin TFA (POL7080) is a highly potent, specific, macrocycle Pseudomonas antibiotic, activates mast cells via MRGPRX2 and MrgprB2.
PC-28185	MtbIMPDH inhibitor 31 Mtb GuaB inhibitor	MtbIMPDH inhibitor 31 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB, MtbIMPDH) with IC50 of 0.52 uM.

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