Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-24340	DNA gyrase inhibitor 35 2088347-91-3	DNA gyrase inhibitor 35 is potent small molecule DNA gyrase inhibitor with IC50 of 1.2 μM of E.coli DNA gyrase, also shows low micromolar inhibition of E. coli topoisomerase IV and of the respective Staphylococcus aureus homologues.
PC-24339	Astrazeneca Arylaminotriazine DNA gyrase inhibitor	Astrazeneca Arylaminotriazine is a promising DNA gyrase inhibitor with profound antibacterial activity.
PC-24338	10-F05 FabH/MiaA inhibitor	10-F05 is a covalent small molecule inhibitor of bacterial β-ketoacyl-acyl carrier protein synthase III (FabH) and MiaA tRNA prenyltransferase, demonstrates broad-spectrum antibacterial effectiveness (MIC=2.5 uM, S. flexneri).
PC-24315	Lariocidin Antibiotic	Lariocidin (LAR) is a novel ribosome-targeting lasso peptide antibiotic inhibit bacterial growth by binding to the ribosome and interfering with protein synthesis.
PC-24305	P2-56-3 Rifampin potentiator	P2-56-3 is small-molecule sensitizer of antibiotic-resistant gram-negative ESKAPE pathogens, potentiates rifampin against antibiotic-resistant strains of Acinetobacter baumannii and Klebsiella pneumoniae, disrupts the outer membrane of A. baumannii.
PC-24304	Rifampin Antibiotic	Rifampin (Rifampicin) is a potent and broad spectrum antibiotic against bacterial pathogens, also has anti-influenza virus and anti-orthopoxvirus activities.
PC-24301	Fosfomycin sodium Antibiotic	Fosfomycin (MK-0955) sodium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis, shows a wide range antibacterial activity, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria.
PC-24300	Fosfomycin calcium Antibiotic	Fosfomycin (MK-0955) calcium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis, shows a wide range antibacterial activity, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria.
PC-24201	ChlaDUB1 inhibitor 27a ChlaDUB1 inhibitor	ChlaDUB1 inhibitor 27a is a specific covalent inhibitor of bacterial chlamydial deubiquitinase 1 (ChlaDUB1) with IC50 of 0.97 uM, inhibits chlamydial growth with IC50 of 25.6 ug/mL.
PC-24194	Xeruborbactam isoboxil Beta-lactamase inhibitor	Xeruborbactam isoboxil is the prodrug of xeruborbactam, an ultrabroad-spectrum beta-lactamase inhibitor, inhibits class A extended-spectrum beta-lactamases with IC50 of 1-3 nM, carbapenemases such as KPC (IC50, 2.9 nM), class C P99 (IC50, 22 nM).
PC-24024	MraY inhibitor 12a MraY inhibitor	MraY inhibitor 12a is a first-in-class, non-nucleoside inhibitor of bacterial enzyme MraY with IC50 of 25 uM, exhibits broad-spectrum antibacterial activity.
PC-23990	Enoxacin DNA Gyrase inhibitor	Enoxacin (Enoxacin sesquihydrate) is a fluoroquinolone antibiotic, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 µg/ml) and topoisomerase IV (IC50=26.5 µg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin shows potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-bi

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