Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-20990	ND-011992 Cyt‐bd inhibitor	ND-011992 is a cytochrome bd oxidase (Cyt‐bd) inhibitor, inhibits Mycobacterium tuberculosis respiratory complex I with IC50 of 0.12 uM, targets respiratory complex I and bo3 oxidase in addition to bd-I and bd-II oxidases.
PC-20704	Min-1 Antibacterial agent	Min-1 is small molecule that inhibits growth of Gram-positive bacteria by targeting the cell envelope, Min-1 is a novel inhibitor of bacterial growth, reduces cell size in Bacillus subtilis.
PC-20696	SK-017154-O PelA inhibitor	SK-017154-O is a specific and noncompetitive inhibitor of PelA, specifically inhibits PelA esterase activity with IC50 of 11 uM, inhibits Pel-dependent PA14 biofilms with IC50 of 1.8 uM.
PC-20672	MK-3402 Metallo-beta-lactamase inhibitor	MK-3402 is a small molecule metallo-beta-lactamase inhibitor with antibiotic activity.
PC-20594	Compound 2B5 S. mutans VicR inhibitor	Compound 2B5 is a potent small molecule against S. mutans with IC50 of 1.9 uM, specifically targets the key response regulator VicR (Kd=87 uM) in both S. mutans and S. aureus.
PC-20585	MAC13243 LolA inhibitor	MAC13243 is a small molecule inhibitor of the bacterial lipoprotein targeting chaperone LolA (Kd=7.5 uM), exhibits potent Gram-negative antibacterial activity with MIC value of 4 ug/mL (Pseudomonas aeruginosa PA01).
PC-20571	IMP-1700 Bacterial AddAB complex inhibitor	IMP-1700 (IMP1700) is a potent, cell-active inhibitor of bacterial AddAB-mediated DNA repair, sensitizes MRSA to ciprofloxacin (CFX) with an EC50 of 5.9 nM.
PC-72742	Irloxacin Antibacterial agent	Irloxacin (Pirfloxacin) is a fluorinated quinolone derivative, is an antibacterial agent with proved activity against both gram-positive and gram-negative bacteria.
PC-72489	LolCDE inhibitor compound 2A LolCDE inhibitor	LolCDE inhibitor compound 2A is a small molecule inhibitor that inhibits the growth of P. aeruginosa by interfering with the function of the lipoprotein transport components LolCDE complex.
PC-72418	COR588 Lysine-gingipain inhibitor	COR588 is a second-generation small-molecule lysine-gingipain (Kgp) inhibitor.
PC-45375	Penicillin G potassium	An antibiotic used to treat a number of bacterial infections..
PC-45181	Vancomycin hydrochloride	An antibiotic used to treat a number of bacterial infections that acts by inhibiting proper cell wall synthesis..

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