Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-23766	MtbFadD32 inhibitor M1 Mtb FadD32 inhibitor	MtbFadD32 inhibitor M1 is a small molecule inhibitor of Mycobacterium tuberculosis fatty acyl-AMP ligase FadD32 and FadD28, shows specific antitubercular activity with IC50 of 4.8 ug/mL, binds and inhibits the FAAL activity of MtbFadD32 and MtbFadD28 enzymes.
PC-23757	STK848198 FtsH inhibitor	STK848198 is a small molecule antimicrobial compound with MIC of 2 ug/mL against S. aureus by targeting ATP‐binding protein FtsH, inhibits methicillin‐sensitive S. aureus, MSRA, VAN intermediate S. aureus (VISA), and DAP‐resistant strains with MIC ranged from 0.5 to 8 ug/mL.
PC-23656	Evybactin M.tb DNA gyrase inhibitor	Evybactin is a potent and selective antibiotic acting against M. tuberculosis (MIC=0.25 ug/mL) targeting DNA gyrase.
PC-23552	(R)-ZG197 SaClpP agonist	(R)-ZG197 is a highly selective S. aureus caseinolytic protease P (SaClpP) activator / agonist with EC50 of 1.5 uM and Kd of 58 nM in BLI assays, 20-fold higher activity than that activates HsClpP.
PC-23551	ZG297 SaClpP agonist	ZG297 is a potent, selective S. aureus caseinolytic protease P (SaClpP) agonist with EC50 of 0.26 uM, without activity against Homo sapiens ClpP (HsClpP) (IC50>100 uM), exerts SaClpP-dependent antistaphylococcal activity.
PC-23524	REP8839 MetRS inhibitor	REP8839 (Bederocin) is a potent inhibitor of S. aureus methionyl-tRNA synthetase (MetRS) with IC50 of <1.9 nM.
PC-23523	DDD806905 MetRS inhibitor	DDD806905 is a highly potent, selective inhibitor of Leishmania donovani methionyl-tRNA synthetase (LdMetRS) with Ki of 18 nM.
PC-23456	Bedaquiline Mycobacterial ATP synthase inhibitor	Bedaquiline fumarate (TMC207, R207910) is a diarylquinoline antibiotic that targets ATP synthase, inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit.
PC-23455	SQ31f Mycobacterial ATP synthase inhibitor	SQ31f is a potent non-tuberculous mycobacteria antibiotic by specifically targeting the mycobacterial F-ATP synthase, inhibits ATP hydrolysis with IC50 of 0.6 uM.
PC-23291	BTI (BrpT Inhibitor) BrpT Inhibitor	BTI (BrpT Inhibitor) is a specific small molecule inhibitor of V. vulnificus transcriptional regulator BrpT with EC50 of 6.48 uM, without affecting bacterial growth or host cell viability.
PC-23266	CBR-5992 Mtb NDH-2 inhibitor	CBR-5992 is a small molecule of Mtb type II NADH dehydrogenase (NDH-2)) inhibitor with ATP IC50 of 2.2 ug/mL, shows MIC90 of 0.5 ug/ mL against Mtb H37Rv.
PC-23224	Iclaprim DHFR inhibitor	Iclaprim (AR-100) is a selective dihydrofolate reductase (DHFR) inhibitor, is active against methicillin, TMP and vancomycin resistant strains, has MIC90 of 0.5 ug/mL against C. trachomatis and C. pneumoniae.

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