Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-28181	Mtb GuaB-IN-2 Mtb GuaB inhibitor	Mtb GuaB-IN-2 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB, IMPDH) with IC50 of 0.2 nM.
PC-28180	Mtb GuaB-IN-1 Mtb GuaB inhibitor	Mtb GuaB-IN-1 (Compound 15) is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB2, IMPDH) with IC50 of 1.7 nM, and MIC of0.26 uM for M.tb H37Ra.
PC-28120	Sulfamethoxazole Antibiotic, DHPS inhibitor	Sulfamethoxazole (Ro 4-2130) is a sulfonamide antibiotic for various bacterial, interferes with folic acid synthesis in susceptible bacteria, is a competitive dihydropteroate synthase (DHPS) inhibitor.
PC-27825	TrmD-IN-4 TrmD inhibitor	TrmD-IN-4 is a potent, covalent inhibitor of bacterial tRNA (m1G37) methyltransferase (TrmD) with IC50 of 4.43 uM, with minimal inhibition of human Trm5, shows selective growth inhibition in bacteria expressing TrmD.
PC-27824	TrmD-IN-3 TrmD inhibitor	TrmD-IN-3 is a potent, covalent inhibitor of bacterial tRNA (m1G37) methyltransferase (TrmD) with IC50 of 1.17 uM for E. coli TrmD, with minimal inhibition of human Trm5 (IC50=2.17 mM), shows selective growth inhibition in bacteria expressing TrmD.
PC-27823	TrmD-IN-2 TrmD inhibitor	TrmD-IN-2 is a potent, covalent inhibitor of bacterial tRNA (m1G37) methyltransferase (TrmD) with IC50 of 0.85 uM for E. coli TrmD, with minimal inhibition of human Trm5 (IC50=1.88 mM), shows selective growth inhibition in bacteria expressing TrmD.
PC-27822	TrmD-IN-1 TrmD inhibitor	TrmD-IN-1 (Compound 8h) is a specific small molecule inhibitor of S. aureus tRNA (m1G37) methyltransferase (TrmD) with KD of 2.48 uM in FP-assays, does not affect Trm5, shows antimicrobial effects at low micromolar concentrations.
PC-27796	Magainin II Antibacterial	Magainin II (Magainin 2) is an antimicrobial peptide isolated from the skin of Xenopus laevis,exhibits antibiotic activity, inhibits growth of numerous species of bacteria and fungi and induce osmotic lysis of protozoa.
PC-27795	Magainin I Antibacterial	Magainin I (Magainin 1) is an antimicrobial peptide isolated from the skin of Xenopus laevis, exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria.
PC-27794	Pexiganan acetate Antibacterial	Pexiganan acetate (MSI-78) is an analog of magainin and orally active antimicrobial peptide with broad-spectrum bactericidal activity, disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis, has MIC90 of ≤ 32 ug/mL for clinical isolates of gram-positive and gram-negative, anaerobic and aerobic bacteria.
PC-27793	Pexiganan Antibacterial	Pexiganan (MSI-78) is an analog of magainin and orally active antimicrobial peptide with broad-spectrum bactericidal activity, disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis, has MIC90 of ≤ 32 ug/mL for clinical isolates of gram-positive and gram-negative, anaerobic and aerobic bacteria.
PC-27726	ACHN-975 TFA LpxC inhibitor	ACHN-975 TFA (ACHN975) is a potent bacterial LpxC inhibitor with IC50 of 0.68 nM (P. aeruginosa LpxC).

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