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CBR-5992

Chemical Structure : CBR-5992

CAS No.: 77517-26-1

CBR-5992 (CBR5992)

Catalog No.: PC-23266Not For Human Use, Lab Use Only.

CBR-5992 is a small molecule of Mtb type II NADH dehydrogenase (NDH-2)) inhibitor with ATP IC50 of 2.2 ug/mL, shows MIC90 of 0.5 ug/ mL against Mtb H37Rv.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CBR-5992 is a small molecule of Mtb type II NADH dehydrogenase (NDH-2)) inhibitor with ATP IC50 of 2.2 ug/mL, shows MIC90 of 0.5 ug/ mL against Mtb H37Rv.

Physicochemical Properties

M.Wt 317.41
Formula C16H19N3O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-cyclohexyl-2-((4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetamide

References

1. Saha P, et al. ACS Infect Dis. 2024 Oct 11;10(10):3699-3711.

2. Harbut, M. B, et al. Angew. Chem., Int. Ed. 2018, 57 (13), 3478– 3482

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