LolCDE-IN-1

Chemical Structure : LolCDE-IN-1

Catalog No.: PC-23141Not For Human Use, Lab Use Only.

LolCDE-IN-1 is a small molecule antibacterial agent targeting the ABC transporter complex LolCDE, inhibits bacterial growth by targeting LolCDE to block lipoprotein transport to the outer membrane.

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Biological Activity

LolCDE-IN-1 is a small molecule antibacterial agent targeting the ABC transporter complex LolCDE, inhibits bacterial growth by targeting LolCDE to block lipoprotein transport to the outer membrane.
LolCDE-IN-1 inhibits E. coli ATCC 25922 and E. coli ATCC 25922 ΔtolCwith MIC with 8 μg/ml and 0.125 μg/ml.

Physicochemical Properties

M.Wt	345.38
Formula	C21H16FN3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3-(3-((4-Fluorobenzyl)oxy)phenyl)-1H-pyrazol-4-yl)pyridine

References

1. Nayar AS, et al. J Bacteriol. 2015 May;197(10):1726-34.

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LolCDE-IN-1

Biological Activity

Physicochemical Properties

References

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