Cat. No. |
Product Name |
Information |
PC-22130 |
Fluorofolin
DHFR inhibitor
|
Fluorofolin is a potent bacterial dihydrofolate reductase (DHFR) inhibitor with IC50 of 2.5 nM for purified E. coli DHFR (FolA), exhibits potent activity against P. aeruginosa PA14 with MIC of 3.1 ug/mL. |
PC-22093 |
X20404
Mtb Pks13 inhibitor
|
X20404 is a small molecule inhibitor of the thioesterase activity of Mtb polyketide synthase 13 (Pks13) with IC50 of 0.4 uM in the Pks13-TE enzyme assay. |
PC-22092 |
EBL-3647
LpxH inhibitor
|
EBL-3647 is a novel LpxH inhibitor with IC50 of 2.2 nM for E. coli LpxH enzyme, shows potent activity targeting lipopolysaccharide synthesis in Gram-negative bacteria (K. pneumoniae ATCC 13883, MIC 0.5 mg/mL). |
PC-22091 |
EBL-3599
LpxH inhibitor
|
EBL-3599 is a novel LpxH inhibitor with IC50 of 3.5 nM for E. coli LpxH enzyme, shows potent activity targeting lipopolysaccharide synthesis in Gram-negative bacteria (K. pneumoniae ATCC 13883, MIC 1 mg/mL). |
PC-22080 |
CDFI
MurJ inhibitor
|
CDFI is a small molecule inhibitor of the bacterial lipid II flippase MurJ, potentiates the activity of β-lactams against MRSA. |
PC-21955 |
S. aureus antibiotic 2
Antibiotic
|
S. aureus antibiotic 2 is a novel antibiotic exhibiting antibiotic activity against Staphylococcus aureus (MIC=4 ug/mL, MRSA USA300), can overcome common resistance determinants and antibiotic tolerance in Gram-positive bacteria. |
PC-21954 |
S. aureus antibiotic 1
Antibiotic
|
S. aureus antibiotic 1 is a novel antibiotic exhibiting antibiotic activity against Staphylococcus aureus (MIC=4 ug/mL, MRSA USA300), can overcome common resistance determinants and antibiotic tolerance in Gram-positive bacteria. |
PC-21953 |
Zosurabalpin
Antibiotic
|
Zosurabalpin is a small-molecule, tethered macrocyclic peptide antibiotic targeting the lipopolysaccharide transporter, has MIC of 0.06 ug/mL A. baumannii ATCC 17978. |
PC-21952 |
RO7075573
Antibiotic
|
RO7075573 is a small-molecule, tethered macrocyclic peptide antibiotic targeting the lipopolysaccharide transporter, has MIC of 0.12 ug/mL A. baumannii ATCC 19606. |
PC-21856 |
Iboxamycin
Antibiotic
|
Iboxamycin (IBX) is a broad-spectrum ribosome-binding antibiotic with potent activity against Gram-positive and Gram-negative bacteria overcomes bacterial multidrug resistance. |
PC-21855 |
Cresomycin
Antibiotic
|
Cresomycin (CRM) is a bridged macrobicyclic antibiotic via inhibiting bacterial ribosome, shows broad efficacy of CRM against clinical isolates of MDR Gram-negative pathogens differentiates the synthetic macrobicyclic class from traditional lincosamides. |
PC-21823 |
AM4085
FmlH Lectin inhibitor
|
AM4085 is a potent, orally bioavailable lectin domain of FmLH antagonist with IC50 of 0.19 uM. |