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Chemical Structure : ML267
CAS No.: 1542213-67-1
Catalog No.: PC-38041Not For Human Use, Lab Use Only.
ML267 (ML 267) is a potent, small-molecule inhibitor of bacterial phosphopantetheinyl transferase Sfp-PPTase with IC50 of 0.29 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 50 mg | $898 | In stock | |
| 100 mg | Get quote |
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ML267 (ML 267) is a potent, small-molecule inhibitor of bacterial phosphopantetheinyl transferase Sfp-PPTase with IC50 of 0.29 uM.
ML267 displays no activity toward the human orthologue (hPPtase).
ML267 attenuates production of an Sfp-PPTase-dependent metabolite when applied to Bacillus subtilis at sublethal doses.
ML267 demonstrates antibacterial activity against methicillin-resistant Staphylococcus aureus, B. subtilis (HM489, IC50=9.3 uM) and chemical genetic studies implicated efflux as a mechanism for resistance in Escherichia coli.
| M.Wt | 431.862 | |
| Formula | C17H17ClF3N5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide |
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1. Foley TL, et al. J Med Chem. 2014 Feb 13;57(3):1063-78.
2. Konno S, et al. Chembiochem. 2017 Sep 19;18(18):1855-1862.
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