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Chemical Structure : TBAJ-876
Catalog No.: PC-38230Not For Human Use, Lab Use Only.
TBAJ-876 (TBAJ876) is a potent inhibitor of mycobacterial F-ATP synthase, inhibits ATP synthesis catalyzed by the mycobacterial F-ATP synthase with IC50 of 0.03 nM.
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TBAJ-876 (TBAJ876) is a potent inhibitor of mycobacterial F-ATP synthase, inhibits ATP synthesis catalyzed by the mycobacterial F-ATP synthase with IC50 of 0.03 nM.
TBAJ-876 shows depleting intrabacterial ATP (IC50=0.89 nM), and inhibiting growth of M. bovis BCG (MIC90=7.2 nM).
TBAJ-876 binds to the ε subunit at BDQ's binding site. TBAJ-876 shows attractive antitubercular activity and efficacy in a murine tuberculosis model.
TBAJ-876 shows attractive in vitro and in vivo activities against M. abscessus, similar to its BDQ parent.
| M.Wt | 657.562 | |
| Formula | C31H37BrN4O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jickky Palmae Sarathy, et al. Antimicrob Agents Chemother. 2019 Sep 23;63(10):e01191-19.
2. Sarathy JP, et al. Antimicrob Agents Chemother. 2020 Jan 27;64(2):e01540-19.
3. Sarathy JP, et al. Antimicrob Agents Chemother. 2020 Mar 24;64(4):e02404-19.
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