Catalog No.: PC-38230Not For Human Use, Lab Use Only.
TBAJ-876 (TBAJ876) is a potent inhibitor of mycobacterial F-ATP synthase, inhibits ATP synthesis catalyzed by the mycobacterial F-ATP synthase with IC50 of 0.03 nM.
TBAJ-876 (TBAJ876) is a potent inhibitor of mycobacterial F-ATP synthase, inhibits ATP synthesis catalyzed by the mycobacterial F-ATP synthase with IC50 of 0.03 nM.
TBAJ-876 shows depleting intrabacterial ATP (IC50=0.89 nM), and inhibiting growth of M. bovis BCG (MIC90=7.2 nM).
TBAJ-876 binds to the ε subunit at BDQ's binding site. TBAJ-876 shows attractive antitubercular activity and efficacy in a murine tuberculosis model.
TBAJ-876 shows attractive in vitro and in vivo activities against M. abscessus, similar to its BDQ parent.
