Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-22091	EBL-3599 LpxH inhibitor	EBL-3599 is a novel LpxH inhibitor with IC50 of 3.5 nM for E. coli LpxH enzyme, shows potent activity targeting lipopolysaccharide synthesis in Gram-negative bacteria (K. pneumoniae ATCC 13883, MIC 1 mg/mL).
PC-22080	CDFI MurJ inhibitor	CDFI is a small molecule inhibitor of the bacterial lipid II flippase MurJ, potentiates the activity of β-lactams against MRSA.
PC-21955	S. aureus antibiotic 2 Antibiotic	S. aureus antibiotic 2 is a novel antibiotic exhibiting antibiotic activity against Staphylococcus aureus (MIC=4 ug/mL, MRSA USA300), can overcome common resistance determinants and antibiotic tolerance in Gram-positive bacteria.
PC-21954	S. aureus antibiotic 1 Antibiotic	S. aureus antibiotic 1 is a novel antibiotic exhibiting antibiotic activity against Staphylococcus aureus (MIC=4 ug/mL, MRSA USA300), can overcome common resistance determinants and antibiotic tolerance in Gram-positive bacteria.
PC-21953	Zosurabalpin Antibiotic	Zosurabalpin is a small-molecule, tethered macrocyclic peptide antibiotic targeting the lipopolysaccharide transporter, has MIC of 0.06 ug/mL A. baumannii ATCC 17978.
PC-21952	RO7075573 Antibiotic	RO7075573 is a small-molecule, tethered macrocyclic peptide antibiotic targeting the lipopolysaccharide transporter, has MIC of 0.12 ug/mL A. baumannii ATCC 19606.
PC-21856	Iboxamycin Antibiotic	Iboxamycin (IBX) is a broad-spectrum ribosome-binding antibiotic with potent activity against Gram-positive and Gram-negative bacteria overcomes bacterial multidrug resistance.
PC-21855	Cresomycin Antibiotic	Cresomycin (CRM) is a bridged macrobicyclic antibiotic via inhibiting bacterial ribosome, shows broad efficacy of CRM against clinical isolates of MDR Gram-negative pathogens differentiates the synthetic macrobicyclic class from traditional lincosamides.
PC-21823	AM4085 FmlH Lectin inhibitor	AM4085 is a potent, orally bioavailable lectin domain of FmLH antagonist with IC50 of 0.19 uM.
PC-21765	Trovafloxacin PANX1 inhibitor	Trovafloxacin is a broad-spectrum quinolone antibiotic, blocks the DNA gyrase and topoisomerase IV activity, also is a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with IC50 of 4 uM for PANX1 inward current.
PC-21689	BDM91288 AcrB efflux pump inhibitor	BDM91288 is a pyridylpiperazine-based AcrB efflux pump inhibitor, potentiate the activity of a panel of antibiotics against K. pneumoniae.
PC-21682	JSF-3269 E. faecium inhibitor	JSF-3269 is a small molecule antibacterial inhibitor against Enterococcus faecium with MIC of 1.9-3.8 uM and minimal bactericidal concentration (MBC) of 7.7-15 uM.

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