Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-72135	UAMC-03011 Anti-trypanosomal	UAMC-03011 is a potent anti-trypanosomal compound (IC50=0.63 uM, T. brucei).
PC-72087	MRL-494 BamA inhibitor	MRL-494 (MRL494) is an antimicrobial small molecule that inhibits assembly of outer membrane proteins (OMPs) by the β-barrel assembly machine (BAM complex), inhibits the insertion of OMPs into the OM by targeting BamA.
PC-72065	Fobrepodacin Bacterial DNA gyrase inhibitor	Fobrepodacin (SR720) is the prodrof form of SPR719, mycobacterial DNA gyrase inhibitor.
PC-72064	SPR719 Bacterial DNA gyrase inhibitor	SPR719 (SPR 719) is a novel mycobacterial DNA gyrase inhibitor with bactericidal properties, inhibits M. abscessu with MIC 0.6 uM (abscessus ATCC 19977).
PC-72063	MMV688844 Bacterial DNA gyrase inhibitor	MMV688844 (MMV844) is a piperidine-4-carboxamide with bactericidal properties against M. abscessus, targets DNA gyrase.
PC-72027	Antimicrobial peptide BING cpxR inhibitor	Antimicrobial peptide BING (IRIILRAQGALKI) is a thermostable 13-residue peptide that targets bacterial envelope stress response by suppressing cpxR expression in Gram-negative bacteria.
PC-38335	BLI-489 Beta-lactamase inhibitor	BLI-489 is a bicyclic penem inhibitor that inhibits class A, C, and D beta-lactamases with synergistic effects with piperacillin.
PC-38313	KBP-7072 Tetracycline antibiotic	Zifanocycline (KBP-7072) is a potent, broad-spectrum, third-generation tetracycline antibacterial.
PC-38312	LPXC-516 LpxC inhibitor	LPXC-516 is a potent bacterial LpxC inhibitor with IC50 of 0.68 nM (P. aeruginosa LpxC), shows potency against the P. aeruginosa isolates with MIC90 of 2 ug/mL.
PC-38311	ACHN-975 LpxC inhibitor	ACHN-975 (ACHN975) is a potent bacterial LpxC inhibitor with IC50 of 0.68 nM (P. aeruginosa LpxC).
PC-38231	GaMF1 F1FO-ATP synthase inhibitor	GaMF1 is a novel antimycobacterial compound that targets the F1FO-ATP synthase γ subunit loop.
PC-38230	TBAJ-876 F-ATP synthase inhibitor	TBAJ-876 (TBAJ876) is a potent inhibitor of mycobacterial F-ATP synthase, inhibits ATP synthesis catalyzed by the mycobacterial F-ATP synthase with IC50 of 0.03 nM.

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