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Chemical Structure : MBL inhibitor 58
Catalog No.: PC-72815Not For Human Use, Lab Use Only.
MBL inhibitor 58 (InCs compound 58) is a potent broad-spectrum metallo-β-lactamase (MBL inhibitor), active against all MBL classes of major clinical relevance
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MBL inhibitor 58 (InCs compound 58) is a potent broad-spectrum metallo-β-lactamase (MBL inhibitor), active against all MBL classes of major clinical relevance.
InCs compound 58 restores carbapenem activity against multiple drug-resistant Gram-negative bacteria and has a low frequency of resistance.
InCs compound 58 also have a good in vivo safety profile, and when combined with meropenem show a strong in vivo efficacy in peritonitis and thigh mouse infection models.
| M.Wt | 529.583 | |
| Formula | C26H28FN3O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jürgen Brem, et al. Nat Chem. 2022 Jan;14(1):15-24.
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