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JCP276

Chemical Structure : JCP276

CAS No.: 131068-67-2

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JCP276 (JCP 276)

Catalog No.: PC-72860Not For Human Use, Lab Use Only.

JCP276 is a novel antibiotic and covalent inhibitor that disrupt M. tuberculosis growth by targeting multiple serine hydrolases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    JCP276 is a novel antibiotic and covalent inhibitor that disrupt M. tuberculosis growth by targeting multiple serine hydrolases.
    JCP276 is a narrow-spectrum inhibitor of Mycobacterium tuberculosis growth.
    JCP276 inhibits multiple nonessential serine hydrolases.
    JCP276 treatment caused accumulation of free lipids and a substantial decrease in lipooligosaccharides, linking SH inhibition to defects in cell envelope biogenesis.

    Physicochemical Properties

    M.Wt 451.70
    Formula C19H16BrClN2O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(3-(3-bromopropoxy)-4-chloro-1-oxo-1H-isochromen-7-yl)-3-phenylurea

    References

    1. Brett M Babin, et al. Cell Chem Biol. 2021 Sep 20;S2451-9456(21)00402-5.

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