| Cat. No. |
Product Name |
Information |
| PC-36100 |
Sibofimloc
FimH inhibitor
|
Sibofimloc (Antibiotic 202) is a small molecule, orally active FimH adhesion inhibitor, shows anti-bacterial infective activity. |
| PC-36063 |
PptT inhibitor 8918
PptT inhibitor
|
PptT inhibitor 8918 (Compound 8918) is a mycobactericidal amidino-urea compound that targets phosphopantetheinyl transferase (PptT, IC50=2.5 uM), shows an MIC90 of 3.1 uM against Mtb H37Rv. |
| PC-36045 |
Didemethylclomipramine
Mtb Topo inhibitor
|
Didemethylclomipramine (Norclomipramine, N-Desmethylcomipramine) is the major active metabolite of the tricyclic antidepressant (TCA) clomipramine. |
| PC-36006 |
ANY1
FosA inhibitor
|
ANY1 (FosA inhibitor ANY1) is a small molecule active site inhibitor of FosA (metal-dependent glutathione S-transferase) with IC50 of 5.1 uM (K. pneumoniae FosA). |
| PC-35948 |
GSK3011724A
KasA inhibitor
|
GSK3011724A (DG167, GSK3011724A) is a potent, specific inhibitor of β-ketoacyl-ACP synthase (KasA, Kd=9 nM), shows anti-tubercular activity (MIC H37Rv=0.8 uM). |
| PC-35941 |
JSF-4088
Antitubercular agent
|
JSF-4088 (JSF4088) is a novel antitubercular agent with potent in vitro antitubercular potency (MIC=19 nM), with no significant Vero cell cytotoxicity (CC50 >120 uM). |
| PC-35875 |
QcrB inhibitor TB47
QcrB inhibitor
|
QcrB inhibitor TB47 (TB47) is a novel antimycobacterial agent that fuctions as a putative respiratory complex III (QcrB) inhibitor with MIC of 0.016-0.5 ug/mL against a panel of 56 M. tuberculosis clinical isolates. |
| PC-35872 |
D13-9001
MexAB-OprM inhibitor
|
D13-9001 (D 13-9001) is a small molecule, MexAB-OprM specific efflux pump inhibitor with good potency in vitro (MPC 2 ug/mL) and displays excellent activity in vivo in a rat pneumonia model of P. aeruginosa. |
| PC-35825 |
Lethal toxin inhibitor DN1
|
Lethal toxin inhibitor DN1 is a small molecule that reduces the cytotoxicity of anthrax lethal toxin (LT) an inhibitor of LT-induced pyroptosis, acts as an antagonist of GPCR receptors type-1 angiotensin II receptor (AGTR1) and apelin receptor (APLNR) with IC50 of 1.958 and 2.280 uM, respectively. |
| PC-35818 |
FtsZ inhibitor C109
FtsZ inhibitor
|
FtsZ inhibitor C109 (Compound 10126109) is a broad spectrum antibacterial compound that inhibits the cell division protein FtsZ, inhibits the FtsZ GTPase activity with IC50 of 8.2 uM. |
| PC-35816 |
AgrA inhibitor F19
AgrA inhibitor
|
AgrA inhibitor F19 is a small-molecule AgrA inhibitor that act as antivirulence agent against Gram-positive pathogens, blocks staphylococcal transcription factor AgrA from binding to its promoter and inhibits toxin and virulence factor transcription. |
| PC-35771 |
SIG1459
Antibacterial, TLR2 inhibitor
|
SIG1459 (SIG-1459) is a novel anti-acne isoprenylcysteine (IPC) small molecule that shows direct antibacterial activity and inhibits TLR2 inflammatory signaling. |
