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Chemical Structure : GaMF1
Catalog No.: PC-38231Not For Human Use, Lab Use Only.
GaMF1 is a novel antimycobacterial compound that targets the F1FO-ATP synthase γ subunit loop.
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GaMF1 is a novel antimycobacterial compound that targets the F1FO-ATP synthase γ subunit loop.
GaMF1 is bactericidal and is active against multidrug- as well as bedaquiline-resistant strains.
Combining GaMF1 with bedaquiline or novel diarylquinoline analogues showed potentiation without inducing genotoxicity or phenotypic changes in a human embryonic stem cell reporter assay.
GaMF1 presents an attractive lead for the discovery of a novel class of anti-tuberculosis F-ATP synthase inhibitors.
| M.Wt | 426.318 | |
| Formula | C20H20BrN5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Adam Hotra, et al. Angew Chem Int Ed Engl. 2020 Aug 3;59(32):13295-13304.
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