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KBP-7072

Chemical Structure : KBP-7072

CAS No.: 1420294-56-9

KBP-7072 (Zifanocycline, KBP7072)

Catalog No.: PC-38313Not For Human Use, Lab Use Only.

Zifanocycline (KBP-7072) is a potent, broad-spectrum, third-generation tetracycline antibacterial.

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    Biological Activity

    Zifanocycline (KBP-7072) is a potent, broad-spectrum, third-generation tetracycline antibacterial.
    KBP-7072 has demonstrated potent in vitro activity against methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae, and vancomycin-resistant enterococci.
    KBP-7072 has received qualified infectious disease product (QIDP) and fast-track status for CAP.

    Physicochemical Properties

    M.Wt 552.628
    Formula C29H36N4O7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (4S,4aS,5aR,12aS)-9-((3-azabicyclo[3.1.0]hexan-3-yl)methyl)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

    References

    1. Huband MD, et al. Antimicrob Agents Chemother. 2020 Apr 21;64(5):e02375-19.

    2. Huband MD, et al. Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0139721.

    3. Han R, et al. Microbiol Spectr. 2022 Feb 9:e0147121. 

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