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Chemical Structure : MRL-494
Catalog No.: PC-72087Not For Human Use, Lab Use Only.
MRL-494 (MRL494) is an antimicrobial small molecule that inhibits assembly of outer membrane proteins (OMPs) by the β-barrel assembly machine (BAM complex), inhibits the insertion of OMPs into the OM by targeting BamA.
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MRL-494 (MRL494) is an antimicrobial small molecule that inhibits assembly of outer membrane proteins (OMPs) by the β-barrel assembly machine (BAM complex), inhibits the insertion of OMPs into the OM by targeting BamA.
MRL-494 exhibited antimicrobial activity against a broad range of bacterial species, impairs biogenesis of OMPs and potentiates rifampicin.
MRL-494 impairs biogenesis of OMPs, BamAE470K provides resistance to MRL-494 and restores OMP biogenesis.
MRL-494 inhibits Gram-positive and -negative microbes through distinct mechanisms of action.
| M.Wt | 622.674 | |
| Formula | C26H35FN16O2 | |
| Appearance | Solid | |
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1. Elizabeth M Hart, et al. Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21748-21757.
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