Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-23201	LPC-011 LpxC inhibitor	LPC-011 is a small-molecule LpxC inhibitor with Ki of 39 nM.
PC-23182	Taniborbactam hydrochloride Beta-lactamase inhibitor	Taniborbactam (VNRX5133) hydrochloride is a highly potent and specific beta-lactamase inhibitor with IC50 of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2 respectively.
PC-23181	BFstatin BrpR inhibitor	BFstatin (175C05) is a small molecule inhibitor of V. vulnificus BrpR with EC50 of 8.01 uM, a transcriptional regulator for biofilm genes.
PC-23145	SPR741 Antibiotic adjuvant	SPR741 (NAB741) is a cationic peptide derived from polymyxin B and antibiotic adjuvant, increases the permeability of the outer membrane of Gram-negative bacteria.
PC-23144	SPR741 acetate Antibiotic adjuvant	SPR741 acetate (NAB741 acetate) is a cationic peptide derived from polymyxin B and antibiotic adjuvant, increases the permeability of the outer membrane of Gram-negative bacteria.
PC-23142	Globomycin LspA inhibitor	Globomycin is a cyclic depsipeptide antibiotic, specific inhibitor of the prolipoprotein signal peptidase, inhibits the essential type II signal peptidase prolipoprotein signal peptidase (LspA), shows antimicrobial effect against Gram-negative bacteria.
PC-23141	LolCDE-IN-1 LolCDE inhibitor	LolCDE-IN-1 is a small molecule antibacterial agent targeting the ABC transporter complex LolCDE, inhibits bacterial growth by targeting LolCDE to block lipoprotein transport to the outer membrane.
PC-23136	MAC-0452936 E. coli Lgt inhibitor	MAC-0452936 is a specific small molecule inhibitor of prolipoprotein diacylglyceryl transferase, Lgt, in Escherichia coli, with IC50 of 1.45 uM (DDM-Lgt).
PC-23128	PTB2 BamA inhibitor	PTB2 is a 14-amino acid macrocyclic peptide BamA inhibitor with MIC of 4 µg/mL (2 µM) against wild-type E. coli, binds to the open lateral gate BamA.
PC-23127	PTB2-1 BamA inhibitor	PTB2-1 is an E. coli-specific BamA inhibitor with MIC of 4 ug/mL, inactive against other bacterial species, decreases OMP levels, decreased activity of the OmpT enzyme, increases outer membrane permeability.
PC-23126	PTB1 BamA inhibitor	Peptide Targeting BamA-1 (PTB1) is a 12-amino acid macrocycle, multi-species BamA inhibitor, binds to purified BamA with SPR Kd of 50 pM, has MIC of 42 ug/mL (25 uM) against wild-type E. coli strain.
PC-22986	G247 MsbA inhibitor	G247 is a specific MsbA inhibitor, reduces MsbA NBD dimerization efficiency and ATPase activity.

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