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Delamanid

Chemical Structure : Delamanid

CAS No.: 681492-22-8

Delamanid (OPC67683;OPC-67683;OPC 67683)

Catalog No.: PC-42715Not For Human Use, Lab Use Only.

Delamanid (OPC-67683) is a mycolic acid biosynthesis inhibitor found to be free of mutagenicity and to possess highly potent activity against tuberculosis, including MDR-TB.

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Biological Activity

Delamanid (OPC-67683) is a mycolic acid biosynthesis inhibitor found to be free of mutagenicity and to possess highly potent activity against tuberculosis, including MDR-TB.
Delamanid (OPC-67683) shows MIC of 0.006-0.024 ug/mL in vitro and highly effective therapeutic activity at low doses in vivo.

Physicochemical Properties

M.Wt 534.4844
Formula C25H25F3N4O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 30 mg/mL

Chemical Name/SMILES

Imidazo[2,1-b]oxazole, 2,3-dihydro-2-methyl-6-nitro-2-[[4-[4-[4-(trifluoromethoxy)phenoxy]-1-piperidinyl]phenoxy]methyl]-, (2R)-

References

1. Matsumoto M, et al. PLoS Med. 2006 Nov;3(11):e466.

2. Li X, et al. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2256-62.

3. Hurdle JG, et al. J Antimicrob Chemother. 2008 Nov;62(5):1037-45.

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