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Chemical Structure : Walrycin B
CAS No.: 878419-78-4
Catalog No.: PC-45436Not For Human Use, Lab Use Only.
Walrycin B is a baterial WalR response regulator, an analogue of toxoflavin and a potent SARS-CoV-2 3CLpro inhibitor with IC50 of 0.26 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $348 | In stock | |
| 100 mg | Get quote |
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Walrycin B is a baterial WalR response regulator, an analogue of toxoflavin and a potent SARS-CoV-2 3CLpro inhibitor with IC50 of 0.26 uM.
Walrycin B simultaneously affects the expression of WalR regulon genes, leading to phenotypes consistent with those of cells starved for the WalK/WalR system and having a bactericidal effect.
Walrycin B shows MICs of 0.39 mg/mL and 3.13 mg/mL against B. subtilis 168 and S. aureus N315, respectively.
Walrycin B also is a separase inhibitor, exerts potent anticancer efficacy in a mouse xenograft model.
Walrycin B has potent activity of inhibiting bacteria growth, and anticancer activity.
| M.Wt | 337.2567 | |
| Formula | C14H10F3N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 11.5 mg/mL |
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| Chemical Name/SMILES |
Pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione, 1,6-dimethyl-3-[4-(trifluoromethyl)phenyl]- |
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1. Gotoh Y, et al. J Antibiot (Tokyo). 2010 Mar;63(3):127-34.
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