Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-61436	CRS3123 MetRS inhibitor	CRS3123 (REP 3123) is a novel diaryldiamine that inhibits bacterial methionyl-tRNA synthetases (MetRS) in Gram-positive bacteria as a novel agent to treat Clostridium difficile infection (CDI).
PC-61388	Macozinone DprE1 inhibitor	Macozinone (PBTZ-169, PBTZ169) is a potent, second-generation antituberculosis agent that inhibits DprE1 and displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.
PC-61371	Contezolid Antibiotic	Contezolid (MRX I) is an orally active oxazolidinone agent with antibacterial activity Gram-positive pathogens, including MRSA, penicillin-PRSP, PISP, and vancomycin-resistant enterococci (VRE) with MIC of 0.25-4 ug/mL.
PC-61295	Murepavadin Antibiotic, MRGPRX2 agonist	Murepavadin (POL7080) is a highly potent, specific, macrocycle Pseudomonas antibiotic, activates mast cells via MRGPRX2 and MrgprB2.
PC-61266	KKL-40	A small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture.
PC-61265	KKL-10	KKL-10 is a small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture.
PC-70355	VU0038882 S. aureus HssRS activator	VU0038882 is a small molecule activator of S. aureus HssRS (heme sensor system) that induces endogenous heme biosynthesis by perturbing central metabolism.
PC-70354	KKL-35 Antibacterial	KKL-35 is a small molecule inhibitor of trans-translation that has broad-spectrum antibiotic activity, inhibits the trans-translation tagging reaction with an IC50 of 0.9 uM.
PC-70348	TCA1 DprE1 inhibitor	TCA1 is a small molecule with activity against drug-resistant and persistent tuberculosis, inhibits DprE1 and MoeW, enzymes involved in cell wall and molybdenum cofactor biosynthesis.
PC-70341	DSM 74 Pf DHODH inhibitor	DSM 74 is a potent, orally active PfDHODH inhibitor (IC50=0.3 uM) with antimalarial activity.
PC-70340	Genz 669178 Pf DHODH inhibitor	Genz 669178 is a potent PfDHODH inhibitor that exhibits low nanomolar in vitro potency against DHODH from P falciparum, P vivax, and P berghei.
PC-70339	IDI-6273 Pf DHODH inhibitor	IDI-6273 is a potent, mutant-selective PfDHODH inhibitor with IC50 of 210 nM for 3D7 E182D PfDHODH.

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