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Chemical Structure : CCG-2979
Catalog No.: PC-62026Not For Human Use, Lab Use Only.
CCG 2979 is a small molecule inhibitor of gene expression of streptokinase (SK), a critical group A streptococcal (GAS) virulence factor.
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CCG-2979 is a small molecule inhibitor of gene expression of streptokinase (SK), a critical group A streptococcal (GAS) virulence factor.
CCG-2979 inhibits expression of SK by 60% at 50 uM based on activity assay, also inhibits the production of active SK protein.
CCG-2979 enhances granulocyte phagocytosis and killing of GAS in an in vitro assay, also protecteds mice from GAS-induced mortality in vivo.
| M.Wt | 394.577 | |
| Formula | C24H30N2OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sun H, et al. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3469-74.
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