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CCG-102487

Chemical Structure : CCG-102487

CAS No.: 353787-50-5

CCG-102487 (CCG102487)

Catalog No.: PC-62027Not For Human Use, Lab Use Only.

CCG 102487 is a CCG-2979 analog that reduces streptokinase (SK) activity with little inhibition of group A streptococcal (GAS) growth.

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    Biological Activity

    CCG-102487 is a CCG-2979 analog that reduces streptokinase (SK) activity with little inhibition of group A streptococcal (GAS) growth.
    CCG-102487 alters the transcript level for key GAS virulence genes, including multiple adhesins (fibronectin binding proteins, collagen-like surface protein, laminin-binding surface protein, and M protein), cytolytic toxins (streptolysins O and S), secreted extracellular proteases (Mac, C5a peptidase, and SpeB), streptodornase Sda1 (DNase), complement inhibitor protein, and streptokinase.

    Physicochemical Properties

    M.Wt 428.594
    Formula C27H28N2OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-benzylsulfanyl-3-prop-2-enylspiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-4-one

    References

    1. Sun H, et al. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3469-74.

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