Inh2-B1 |CAS:690216-38-7 Probechem Biochemicals

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Chemical Structure : Inh2-B1

Inh2-B1 (STK1 inhibitor B1)

Catalog No.: PC-61783Not For Human Use, Lab Use Only.

Inh2-B1 (STK1 inhibitor B1) is a novel specific S aureus Ser/Thr protein kinase (STK1) inhibitor with IC50 of 49 uM, directly binds to ATP-binding catalytic domain.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Inh2-B1 (STK1 inhibitor B1) is a novel specific S aureus Ser/Thr protein kinase (STK1) inhibitor with IC50 of 49 uM, directly binds to ATP-binding catalytic domain.
Inh2-B1 exhibits in vitro growth inhibition of MRSA, and in vivo protection in mice against the lethal MRSA challenge.
Inh2-B1 down-regulates cell wall hydrolase genes and disrupts the biofilm formation of MRSA.

Physicochemical Properties

M.Wt	411.45
Formula	C19H13N3O4S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl 5-oxo-3-(phenyl carbamoyl)-1-thioxo-4,5dihydro[1,3]thiazolo[3,4-a]quinazoline-8-carboxylate

References

1. Kant S, et al. Sci Rep. 2017 Jul 11;7(1):5067.

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Inh2-B1 (STK1 inhibitor B1)

Biological Activity

Physicochemical Properties

References

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