| Cat. No. |
Product Name |
Information |
| PC-28033 |
3OC12-HSL
Quorum-sensing molecule
|
3OC12-HSL is a P. aeruginosa quorum-sensing molecule, triggers quorum-sensing signal cascade, interacts with signal receptor-transcription factors LasR and QscR. |
| PC-27995 |
BVL3572S
Mtb HisC/AlaA inhibitor
|
BVL3572S is a potent bactericidal compound potently inhibits Mtb growth (MIC90=1.7 uM, Mtb H37Rv) and is bactericidal, inhibits two essential pyridoxal phosphate (PLP)-dependent aminotransferases HisC and AlaA, disrupting L-His and L-Ala biosynthesis. |
| PC-27987 |
Obafluorin
Antibiotic, ThrRS inhibitor
|
Obafluorin is a beta-lactone antibiotic with activity against both Gram-positive and -negative pathogens, inhibits E. coli and P. fluorescens threonyl-tRNA synthetase (ThrRS, TRS) with IC50 of 35 nM and 4.3 nM respectively. |
| PC-27731 |
Afabicin
FabI inhibitor
|
Afabicin (Debio 1450, AFN-1720) is an antibiotic targets the staphylococcal enoyl-acyl carrier protein reductase (FabI) and exhibits selective potent antibacterial activity against staphylococcal species, including MRSA, |
| PC-27472 |
Luxafimloc
FimH inhibitor
|
Luxafimloc (GSK3882347) is a small molecule Escherichia coli fimbrial (FimH) adhesin inhibitor. |
| PC-27208 |
Kalamycin
METTL1 inhibitor, Antibiotic
|
Kalamycin (Kalafungin, U-19718, NSC137443) is an antibiotic, antimicrobial agent and β-lactamase inhibitor from marine Streptomyces, also is a potent inhibitor of METTL1 methyltransferase activity with IC50 of 8.9 uM, demonstrates potent antileukemia efficacy, also shows inhibitory activities against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria. |
| PC-27159 |
UCP1172
DHFR inhibitor, Antifolate
|
UCP1172 is an antibacterial dihydrofolate reductase (DHFR) inhibitor with IC50 of 8.9 nM, 220 nM, 410 nM and 30 nM for S. aureus DfrB (wt SaDHFR), DfrG, DfrA and DfrK, inhibits MRSA isolates with MIC50 of 0.625 ug/mL for UCH MRSA 1 (dfrG). |
| PC-26790 |
Forazemin
Peptide deformylase inhibitor
|
Forazemin (BB-83698) is a potent, orally active peptide deformylase (PDF) inhibitor, shows antibacterial potency for gram-positive pathogens with MIC50 of 0.25 ug/mL and 0.06 ug/mL for Streptococcus pneumoniae and Moraxella catarrhalis. |
| PC-26720 |
KGDI-109
PgDPP7 inhibitor
|
KGDI-109 is the first substrate-mimetic dipeptide inhibitor of P. gingivalis dipeptidyl peptidase 7 (PgDPP7) with IC50 of 53.8 uM and Ki of 25.1 uM, exerts an inhibitory effect against P. gingivalis growth with MIC of 1.56 uM. |
| PC-26666 |
MSU-155
MmpL3 inhibitor
|
MSU-155 is small molecule inhibitor targeting MmpL3 in Mycobacterium abscessus, has MIC50 of 0.21 uM and trigger a dose-dependent ATP increase with in Mycobacterium abscessus. |
| PC-26607 |
VNRX-14079
N. gonorrhoeae PBP2 inhibitor
|
VNRX-14079 is a specific Neisseria gonorrhoeae penicillin-binding protein (PBP2) inhibitor with IC50 of 1.7 uM for N. gonorrhoeae FA19 strain, exhibits potent antibacterial activity against multidrug-resistant N. gonorrhoeae through high-affinity binding to the PBP2. |
| PC-26321 |
Cefidelbaz
Cephalosporin antibiotic
|
Cefidelbaz is a cephalosporin antibiotic with significant antibacterial activity against gram-negative bacterium with MICs of 0.125-0.5, 0.125-0.5 and 0.125-2 μg/mL for carbapenem-resistant Acinetobacter baumannii (CRAB), Klebsiella pneumoniae (CRE) and Pseudomonas aeruginosa (CRPA), respectively. |
