Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-21689	BDM91288 AcrB efflux pump inhibitor	BDM91288 is a pyridylpiperazine-based AcrB efflux pump inhibitor, potentiates the activity of a panel of antibiotics against K. pneumoniae.
PC-21661	TBAJ-5307 Non-tuberculous mycobacteria inhibitor	TBAJ-5307 is a broad spectrum anti-non-tuberculous mycobacteria (NTM) inhibitor targeting FO-domain of F1FO-ATP synthase, shows MIC50 of 4.5 nM and 6 nM against the Mab subsp. abscessus smooth strain and rough strain respectively.
PC-21552	SMT-738 LolCDE inhibitor	SMT-738 is a small-molecule inhibitor of bacterial lipoprotein transport complex (LolCDE), shows potent and highly selective antimicrobial activity.
PC-21546	SQ109 Mtb MmpL3 inhibitor	SQ109 (NSC 722041) is an ethambutol (EMB) analog and antitubercular agent targeting MmpL3, shows MICs of 1-0.5 uM.
PC-20744	MAC13772 BioA inhibitor	MAC13772 is a small molecule inhibitor of bacterial enzyme BioA with IC50 of 250 nM, the antepenultimate step in biotin biosynthesis, MAC13772 inhibits biotin biosynthesis.
PC-20706	Durlobactam sodium Beta-lactamase inhibitor	Durlobactam (ETX2514) sodium is a broad-spectrum β-lactamase inhibitor with IC50 of 4, 14 and 190 nM for class A β-lactamase KPC-2, class AmpC and class D OXA-24, respectively.
PC-20585	MAC13243 LolA inhibitor	MAC13243 is a small molecule inhibitor of the bacterial lipoprotein targeting chaperone LolA (Kd=7.5 uM), exhibits potent Gram-negative antibacterial activity with MIC value of 4 ug/mL (Pseudomonas aeruginosa PA01).
PC-20570	ML328 Bacterial AddAB complex inhibitor	ML328 is a first-in-class, dual inhibitor of bacterial AddAB and RecBCD helicase-nucleases with IC50 of 15.7 and 4.8 uM, respectively.
PC-20322	Regacin RegA inhibitor	Regacin is a potent, specific inhibitor of bacterial AraC-like virulence regulator RegA with IC50 of 1.7 uM.
PC-20319	Savirin AgrA inhibitor	Savirin (S. aureus virulence inhibitor) is a small molecule inhibitor inhibiting agr quorum sensing in S. aureus by blocking the transcriptional function of AgrA.
PC-20099	MMV1091186 P.f cIRS inhibitor	MMV1091186 (MMV 1091186) is an antimalarial compound that inhibit P. falciparum cytoplasmic isoleucyl tRNA synthetase (cIRS) with IC50 of 0.87 uM.
PC-20097	GSK030 Antimalarial	GSK030 (GSK3212030A) is an antimalarial compound that targets blood-stage activity of the Plasmodium falciparum and Plasmodium vivax parasites.

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