| Cat. No. |
Product Name |
Information |
| PC-28119 |
CpxRA inhibitor Cpx26
CpxRA inhibitor
|
CpxRA inhibitor Cpx26 is a small-molecule CpxRA phosphatase inhibitor with EC50 of 1.1 uM, significantly inhibits Uropathogenic Escherichia coli swimming motility, biofilm formation, and adhesion to bladder epithelial cells. |
| PC-28084 |
DnaK inhibitor M7
DnaK inhibitor
|
DnaK inhibitor M7 is a small molecule inhibitor of bacterial Hsp70 protein DnaK ATPase, inhibits DnaK-mediated ATP hydrolysis with IC50 of 8.4 uM, likely engages the substrate-binding pocket of DnaK, induces accumulation of σ-32 without affecting protein translation, effectively inhibits the growth of E. coli AS19 and some Gram-positive bacteria, including Staphylococcus aureus and Bacillus cereus. |
| PC-28034 |
N-butyryl-L-homoserine lactone
Quorum-sensing molecule
|
N-Butanoyl-L-homoserine lactone (C4-HSL) is a Pseudomonas aeruginosa quorum-sensing signal molecule, blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa, also is a cleavable ADC linker for synthesis of ADCs. |
| PC-28033 |
3OC12-HSL
Quorum-sensing molecule
|
3OC12-HSL is a P. aeruginosa quorum-sensing molecule, triggers quorum-sensing signal cascade, interacts with signal receptor-transcription factors LasR and QscR. |
| PC-27995 |
BVL3572S
Mtb HisC/AlaA inhibitor
|
BVL3572S is a potent bactericidal compound potently inhibits Mtb growth (MIC90=1.7 uM, Mtb H37Rv) and is bactericidal, inhibits two essential pyridoxal phosphate (PLP)-dependent aminotransferases HisC and AlaA, disrupting L-His and L-Ala biosynthesis. |
| PC-27987 |
Obafluorin
Antibiotic, ThrRS inhibitor
|
Obafluorin is a beta-lactone antibiotic with activity against both Gram-positive and -negative pathogens, inhibits E. coli and P. fluorescens threonyl-tRNA synthetase (ThrRS, TRS) with IC50 of 35 nM and 4.3 nM respectively. |
| PC-27731 |
Afabicin
FabI inhibitor
|
Afabicin (Debio 1450, AFN-1720) is an antibiotic targets the staphylococcal enoyl-acyl carrier protein reductase (FabI) and exhibits selective potent antibacterial activity against staphylococcal species, including MRSA, |
| PC-27472 |
Luxafimloc
FimH inhibitor
|
Luxafimloc (GSK3882347) is a small molecule Escherichia coli fimbrial (FimH) adhesin inhibitor. |
| PC-27208 |
Kalamycin
METTL1 inhibitor, Antibiotic
|
Kalamycin (Kalafungin, U-19718, NSC137443) is an antibiotic, antimicrobial agent and β-lactamase inhibitor from marine Streptomyces, also is a potent inhibitor of METTL1 methyltransferase activity with IC50 of 8.9 uM, demonstrates potent antileukemia efficacy, also shows inhibitory activities against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria. |
| PC-27159 |
UCP1172
DHFR inhibitor, Antifolate
|
UCP1172 is an antibacterial dihydrofolate reductase (DHFR) inhibitor with IC50 of 8.9 nM, 220 nM, 410 nM and 30 nM for S. aureus DfrB (wt SaDHFR), DfrG, DfrA and DfrK, inhibits MRSA isolates with MIC50 of 0.625 ug/mL for UCH MRSA 1 (dfrG). |
| PC-27134 |
ZN148
Metallo-β-lactamase inhibitor
|
ZN148 (APC148) is a specific, irreversible, zinc-chelating metallo-β-lactamase (MBL) inhibitor with broad activity against Ambler class B enzymes, including NDM, VIM, and IMP, restores the in vitro and in vivo activity of meropenem against multidrug-resistant MBL-producing Enterobacterales. |
| PC-26790 |
Forazemin
Peptide deformylase inhibitor
|
Forazemin (BB-83698) is a potent, orally active peptide deformylase (PDF) inhibitor, shows antibacterial potency for gram-positive pathogens with MIC50 of 0.25 ug/mL and 0.06 ug/mL for Streptococcus pneumoniae and Moraxella catarrhalis. |
