| Cat. No. |
Product Name |
Information |
| PC-24236 |
FBX-1991
H. pylori FabX inhibitor
|
FBX-1991 is a potent, specific small molecule inhibitor of Helicobacter pylori (H. pylori) dehydrogenase/isomerase FabX with IC50 of 0.158 uM, shows potent antibacterial activity against strain BHKS211 with MIC of 16 ug/mL. |
| PC-24195 |
Xeruborbactam disodium
Beta-lactamase inhibitor
|
Xeruborbactam (QPX7728) disodium is an ultrabroad-spectrum beta-lactamase inhibitor, inhibits class A extended-spectrum beta-lactamases with IC50 of 1-3 nM, carbapenemases such as KPC (IC50, 2.9 nM), class C P99 (IC50, 22 nM). |
| PC-23867 |
BRD1401
OprH-LPS inhibitor
|
BRD1401 is a P. aeruginosa-specific inhibitor targeting outer membrane protein OprH-LPS interaction, increases membrane fluidity. |
| PC-23749 |
Benurestat
Urease inhibitor
|
Benurestat is a reversible competitive inhibitor of gut bacterial urease, inhibits ammonia production by urease-encoding gut bacteria, inhibits urease activity in mouse fecal suspensions ex vivo with IC50 of 2.5 uM. |
| PC-23591 |
Miltefosine
CCR5 agonist
|
Miltefosine is a phosphatidylcholine analog with anti-leishmanial activity, inhibits PI3K/Akt activity, shows broad spectrum antimicrobial, anti-leishmanial and anticoronaviral activity. |
| PC-23309 |
MRS-2541
MetRS inhibitor
|
MRS-2541 a novel potent inhibitor of methionyl-tRNA synthetase (MetRS) with selective activity against gram-positive bacteria with MIC of 0.063-0.5 ug/mL against Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus species. |
| PC-23266 |
CBR-5992
Mtb NDH-2 inhibitor
|
CBR-5992 is a small molecule of Mtb type II NADH dehydrogenase (NDH-2) inhibitor with ATP IC50 of 2.2 ug/mL, shows MIC90 of 0.5 ug/ mL against Mtb H37Rv. |
| PC-23241 |
Zidebactam
β-lactam enhancer
|
Zidebactam (WCK-5107) is a β-Lactam Enhancer, inhibitor of class A, class C and some class D β-lactamases with MIC of <2 ug/mL for most Escherichia coli, Klebsiella, Citrobacter and Enterobacter spp., also binds to penicillin-binding protein2 (PBP2). |
| PC-23202 |
CHIR-090
LpxC inhibitor
|
CHIR-090 is a potent, slow, tight-binding inhibitor of the LpxC deacetylase, binds to E. coli LpxC with Ki of 4.0 nM, displays good antimicrobial activity against several Gram-negative bacteria. |
| PC-23182 |
Taniborbactam hydrochloride
Beta-lactamase inhibitor
|
Taniborbactam (VNRX5133) hydrochloride is a highly potent and specific beta-lactamase inhibitor with IC50 of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2 respectively. |
| PC-23181 |
BFstatin
BrpR inhibitor
|
BFstatin (175C05) is a small molecule inhibitor of V. vulnificus BrpR with EC50 of 8.01 uM, a transcriptional regulator for biofilm genes. |
| PC-22815 |
VOMG
M. abscessus inhibitor
|
VOMG is a small molecule compound active against Mycobacterium abscessus (Mab, MIC=0.25 ug/mL) and other pathogens by inhibiting cell division. |
