| Cat. No. |
Product Name |
Information |
| PC-23591 |
Miltefosine
CCR5 agonist
|
Miltefosine is a phosphatidylcholine analog with anti-leishmanial activity, inhibits PI3K/Akt activity, shows broad spectrum antimicrobial, anti-leishmanial and anticoronaviral activity. |
| PC-23309 |
MRS-2541
MetRS inhibitor
|
MRS-2541 a novel potent inhibitor of methionyl-tRNA synthetase (MetRS) with selective activity against gram-positive bacteria with MIC of 0.063-0.5 ug/mL against Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus species. |
| PC-23241 |
Zidebactam
β-lactam enhancer
|
Zidebactam (WCK-5107) is a β-Lactam Enhancer, inhibitor of class A, class C and some class D β-lactamases with MIC of <2 ug/mL for most Escherichia coli, Klebsiella, Citrobacter and Enterobacter spp., also binds to penicillin-binding protein2 (PBP2). |
| PC-23202 |
CHIR-090
LpxC inhibitor
|
CHIR-090 is a potent, slow, tight-binding inhibitor of the LpxC deacetylase, binds to E. coli LpxC with Ki of 4.0 nM, displays good antimicrobial activity against several Gram-negative bacteria. |
| PC-23182 |
Taniborbactam hydrochloride
Beta-lactamase inhibitor
|
Taniborbactam (VNRX5133) hydrochloride is a highly potent and specific beta-lactamase inhibitor with IC50 of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2 respectively. |
| PC-23181 |
BFstatin
BrpR inhibitor
|
BFstatin (175C05) is a small molecule inhibitor of V. vulnificus BrpR with EC50 of 8.01 uM, a transcriptional regulator for biofilm genes. |
| PC-22815 |
VOMG
M. abscessus inhibitor
|
VOMG is a small molecule compound active against Mycobacterium abscessus (Mab, MIC=0.25 ug/mL) and other pathogens by inhibiting cell division. |
| PC-22662 |
Brodimoprim
DHFR inhibitor
|
Brodimoprim (Ro 10-5970) is a trimethoprim analogue and orally active dihydrofolate reductase (DHFR) inhibitor, shows acitvity against a wide range of Gram-positive and Gram-negative aerobic bacteria. |
| PC-22658 |
KSP-1007
β-lactamase inhibitor
|
KSP-1007 is a potent, broad-spectrum boronic acid β-lactamase inhibitor, strongly inhibits class A carbapenemase KPCs with Ki app values of 0.836-2.19 nM, inhibits all β-lactamases from classes A, B, C, and D, enhances meropenem against carbapenem-resistant Gram-negative bacteria. |
| PC-22567 |
OXF-077
SOS response inhibitor, SpsB inhibitor
|
OXF-077 is a potent inhibitor of the mutagenic SOS response, suppresses the rate of ciprofloxacin resistance emergence in S. aureus, is a potentiator of DNA-damage in MRSA, directly targets signal peptidase IB (SpsB). |
| PC-22556 |
LEI-800
Bacterial DNA gyrase inhibitor
|
LEI-800 is potent antibacterial as an allosteric bacterial topoisomerase DNA gyrase inhibitor with MIC of 3.1 uM and 6.25 uM for E. coli and K. pneumoniae respectively, inhibits the ATP-dependent supercoiling activity of recombinant E. coli DNA gyrase in a gel-based assay with IC50 of 35 nM. |
| PC-22472 |
BTZ043
DprE1 inhibitor
|
BTZ043 (BTZ-043) is a small molecule antimycobacterial agent taregting the DprE1 (Rv3790) subunit of the enzyme decaprenylphosphoryl-beta-d-ribose 2'-epimerase, shows MIC values of 1 ng/ml (2.3 nM) and 4 ng/ml (9.2 nM) against M. tuberculosis H37Rv and Mycobacterium smegmatis, respectively. |
