Benurestat

Chemical Structure : Benurestat

Catalog No.: PC-23749Not For Human Use, Lab Use Only.

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Biological Activity

Benurestat is a reversible competitive inhibitor of gut bacterial urease, inhibits ammonia production by urease-encoding gut bacteria, inhibits urease activity in mouse fecal suspensions ex vivo with IC50 of 2.5 uM.
Benurestat inhibits saw ammonia production in cultured P. mirabilis with IC50 of 69.9 uM.
Benurestat treatment reduces fecal and serum ammonia levels in mice, also rescues mice from otherwise lethal acute liver injury.

Physicochemical Properties

M.Wt	228.63
Formula	C9H9ClN2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Chloro-N-(2-(hydroxyamino)-2-oxoethyl)benzamide

References

1. Richards-Corke KC, et al. ACS Chem Biol. 2025 Jan 8. doi: 10.1021/acschembio.3c00556.

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Benurestat

Biological Activity

Physicochemical Properties

References

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