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Chemical Structure : CHIR-090
Catalog No.: PC-23202Not For Human Use, Lab Use Only.
CHIR-090 is a potent, slow, tight-binding inhibitor of the LpxC deacetylase, binds to E. coli LpxC with Ki of 4.0 nM, displays good antimicrobial activity against several Gram-negative bacteria.
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CHIR-090 is a potent, slow, tight-binding inhibitor of the LpxC deacetylase, binds to E. coli LpxC with Ki of 4.0 nM, displays good antimicrobial activity against several Gram-negative bacteria.
| M.Wt | 437.50 | |
| Formula | C24H27N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. McClerren AL, et al. Biochemistry. 2005 Dec 20;44(50):16574-83.
2. Barb AW, et al. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18433-8.
3. Bodewits K, et al. Antimicrob Agents Chemother. 2010 Aug;54(8):3531-3.
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