Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-61004	GSK-729 EchA6 inhibitor	GSK-729 (GSK729) is a potent, small molecule inhibitor of Mycobacterium tuberculosis enoyl-coenzyme A (CoA) hydratase EchA6 with IC50 of 1.8 uM, but not the MmpL3.
PC-60900	M4284 FimH inhibitor	M4284 (M-4284) is a high-affinity biphenyl mannoside FimH inhibitor with HAI of 16 nM in hemagglutination assay.
PC-60869	NSC624548 Antibacterial	NSC624548 (HO-221) is a small molecule that inhibits the activities of E. coli DNA polymerase I and calf thymus DNA polymerase alpha.
PC-70214	BRD4592 Mtb tryptophan synthase inhibitor	BRD4592 is a small-molecule, allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase (TrpAB), binds at the TrpAB α-β-subunit interface with IC50 of 70.9 nM and 22.6 nM for α-subunit and β-subunit, respectively.
PC-60475	Zoliflodacin DNA gyrase inhibitor	Zoliflodacin (AZD0914, ETX0914) is a novel DNA gyrase inhibitor that inhibits bacterial DNA biosynthesis, has potent in vitro activity against many different bacterial species with MIC of 0.004 to 0.25 ug/ml.
PC-60356	TAM-16 M. tuberculosis Pks13 inhibitor	TAM-16 is a benzofuran class inhibitor of M. tuberculosis Pks13 (Polyketide Synthase 13 with IC50 of 0.32 uM.
PC-70181	RWJ-49815 Kinase A inhibitor	RWJ-49815 is a potent bactericidal agent that inhibits the KinA autophosphorylation with IC50 of 1.6 uM.
PC-70093	Roseoflavin Antibiotic	Roseoflavin is a chemical analog of FMN and riboflavin that has antimicrobial activity.
PC-70018	GSK1322322 Peptide deformylase inhibitor	Lanopepden (GSK1322322) is a novel antibacterial agent that targets bacterial peptide deformylase (PDF), inhibits PDF activity and prevents bacterial protein synthesis.
PC-60091	GSK-656 Mtb LeuRS inhibitor	GSK-656 (Ganfeborole; GSK-3036656, GSK656) is a potent, highly selective,orally bioavailable Mtb Leucyl-tRNA synthetase (LeuRS) with IC50 of 0.2 uM.
PC-60061	LL-3858 dihydrchloride Anti-tuberculosis agent	Sudoterb (LL-3858) dihydrchloride is a novel anti-TB agent that has an MIC range of 0.06-0.5 ug/mL.
PC-60060	LL-3858 Anti-tuberculosis agent	Sudoterb (LL-3858, LL3858) is a novel anti-TB agent that has an MIC range of 0.06-0.5 ug/mL.

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