Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : GSK-729
Catalog No.: PC-61004Not For Human Use, Lab Use Only.
GSK-729 (GSK729) is a potent, small molecule inhibitor of Mycobacterium tuberculosis enoyl-coenzyme A (CoA) hydratase EchA6 with IC50 of 1.8 uM, but not the MmpL3.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
GSK-729 (GSK729) is a potent, small molecule inhibitor of Mycobacterium tuberculosis enoyl-coenzyme A (CoA) hydratase EchA6 with IC50 of 1.8 uM, but not the MmpL3.
GSK-729 selectively pulls down EchA6 in a stereospecific manner in M. bovis BCG extracts, competes with CoA-binding.
GSK-729 suppresses mycolic acid synthesis, and are bactericidal in mouse model of chronic tuberculosis infection.
| M.Wt | 339.318 | |
| Formula | C16H16F3N3O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Cox JA, et al. Nat Microbiol. 2016 Jan 18;1:15006.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
