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Chemical Structure : GSK951A
Catalog No.: PC-61005Not For Human Use, Lab Use Only.
GSK951A is a small molecule with bactericidal efficacy against Mycobacterium tuberculosis with H37Rv MIC of 0.16 uM, targets enoyl-coenzyme A (CoA) hydratase EchA6 with binding Kd of 0.45 uM.
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GSK951A is a small molecule with bactericidal efficacy against Mycobacterium tuberculosis with H37Rv MIC of 0.16 uM, targets enoyl-coenzyme A (CoA) hydratase EchA6 with binding Kd of 0.45 uM.
GSK951A suppresses mycolic acid synthesis and EchA6 is essential, and are bactericidal in mouse model of chronic tuberculosis infection.
| M.Wt | 472.468 | |
| Formula | C24H23F3N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cox JA, et al. Nat Microbiol. 2016 Jan 18;1:15006.
2. Remuiñán MJ, et al. PLoS One. 2013 Apr 17;8(4):e60933.
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