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Chemical Structure : DSM 74
Catalog No.: PC-70341Not For Human Use, Lab Use Only.
DSM 74 is a potent, orally active PfDHODH inhibitor (IC50=0.3 uM) with antimalarial activity.
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DSM 74 is a potent, orally active PfDHODH inhibitor (IC50=0.3 uM) with antimalarial activity.
DSM 74 shows good plasma exposure in mice and is equally potent against PfDHODH and PbDHODH.
DSM 74 suppresses growth of P. berghei in mice after oral administration.
| M.Wt | 293.253 | |
| Formula | C13H10F3N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lukens AK, e tal. Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):799-804.
2. Gujjar R, et al. J Med Chem. 2009 Apr 9;52(7):1864-72.
3. Lee JJ, et al. urr Microbiol. 2014 Sep;69(3):286-91.
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