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IDI-6273

Chemical Structure : IDI-6273

CAS No.: 433945-73-4

IDI-6273 (IDI6273)

Catalog No.: PC-70339Not For Human Use, Lab Use Only.

IDI-6273 is a potent, mutant-selective PfDHODH inhibitor with IC50 of 210 nM for 3D7 E182D PfDHODH.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    IDI-6273 is a potent, mutant-selective PfDHODH inhibitor with IC50 of 210 nM for 3D7 E182D PfDHODH.
    IDI-6273 displays 10.95-fold more active against 3D7 E182D than 3D7.
    IDI-6273 does not yield resistant parasites with a combination of Genz-669178.

    Physicochemical Properties

    M.Wt 341.835
    Formula C20H20ClNO2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-(4-chlorobenzyl)-8-ethoxy-1,3-dimethylcyclohepta[c]pyrrol-4(2H)-one

    References

    1. Lukens AK, e tal. Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):799-804.

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