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Chemical Structure : M4284
Catalog No.: PC-60900Not For Human Use, Lab Use Only.
M4284 (M-4284) is a high-affinity biphenyl mannoside FimH inhibitor with HAI of 16 nM in hemagglutination assay.
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M4284 (M-4284) is a high-affinity biphenyl mannoside FimH inhibitor with HAI of 16 nM in hemagglutination assay; reduces intestinal colonization of genetically diverse UPEC isolates, while simultaneously treating UTI, without notably disrupting the structural configuration of the gut microbiota; reduces UTI89 levels in the gut and urinary tracts of mice.
| M.Wt | 460.483 | |
| Formula | C23H28N2O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Spaulding CN, et al. Nature. 2017 Jun 22;546(7659):528-532.
2. Jarvis C, et al. ChemMedChem. 2016 Feb 17;11(4):367-73.
3. Han Z, et al. J Med Chem. 2012 Apr 26;55(8):3945-59.
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