Chemical Structure : M4284
CAS No.: 1373346-85-0
Catalog No.: PC-60900Not For Human Use, Lab Use Only.
M4284 (M-4284) is a high-affinity biphenyl mannoside FimH inhibitor with HAI of 16 nM in hemagglutination assay.
Packing | Price | Stock | Quantity |
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5 mg | $258 | In stock | |
10 mg | $398 | In stock | |
25 mg | $598 | In stock | |
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M4284 (M-4284) is a high-affinity biphenyl mannoside FimH inhibitor with HAI of 16 nM in hemagglutination assay.
M4284 reduces intestinal colonization of genetically diverse UPEC isolates, while simultaneously treating UTI, without notably disrupting the structural configuration of the gut microbiota.
M4284 reduces UTI89 levels in the gut and urinary tracts of mice.
M.Wt | 460.483 | |
Formula | C23H28N2O8 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
N3,N5,3'-trimethyl-4'-(((3S,4R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-[1,1'-biphenyl]-3,5-dicarboxamide |
1. Spaulding CN, et al. Nature. 2017 Jun 22;546(7659):528-532.
2. Jarvis C, et al. ChemMedChem. 2016 Feb 17;11(4):367-73.
3. Han Z, et al. J Med Chem. 2012 Apr 26;55(8):3945-59.
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