Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-47423	Norvancomycin hydrochloride Antibiotic	Norvancomycin hydrochloride (Desmethyl-vancomycin hydrochloride) is an antibiotic used to treat a number of bacterial infections that acts by inhibiting proper cell wall synthesis.
PC-46819	Vancomycin Antibiotic	Vancomycin is an antibiotic used to treat a number of bacterial infections that acts by inhibiting proper cell wall synthesis.
PC-45750	Vaborbactam serine β-lactamase inhibitor	Vaborbactam (RPX-7009) is a serine β-lactamase inhibitor that notably restores the activity of carbapenems against KPC-producing strains.
PC-45277	Garenoxacin mesylate hydrate Antibiotic	Garenoxacin mesylate hydrate (BMS284756) is a quinolone antibiotic for the treatment of Gram-positive and Gram-negative bacterial infections.
PC-42192	DprE1-IN-25 DprE1 inhibitor	DprE1-IN-25 is a potent, noncovalent DprE1 inhibitor with IC50 of 43 nM, shows activity against Mycobacterium tuberculosis (Mtb) in vitro with MIC of 0.39 uM.
PC-45087	AFN-1252 FabI inhibitor	AFN-1252 (API-1252, Debio 1452) is a potent inhibitor of bacterial enoyl-ACP reductase FabI.
PC-45070	Relebactam β-lactamase inhibitor	Relebactam (MK-7655) is a novel β-lactamase inhibitor that inhibited both class A and C β-lactamases in vitro.
PC-45372	Dalbavancin Antibiotic	Dalbavancin (MDL-63397, BI-397) is a novel second-generation lipoglycopeptide antibiotic with MIC90 values of 0.06 μg/mL and 0.25 μg/mL for Staphylococcus aureus and Bacillus anthracis, respectively.
PC-42302	Q203 Mtb QcrB inhibitor	Telacebec (Q203, IAP6) is a novel potent anti-tuberculosis agent targeting cytochrome b subunit qcrB, inhibits M. tuberculosis H37Rv with MIC50 of of 2.7 nM.
PC-45436	Walrycin B Baterial WalR regulator, 3CLpro inhibitor	Walrycin B is a baterial WalR response regulator, an analogue of toxoflavin and a potent SARS-CoV-2 3CLpro inhibitor with IC50 of 0.26 uM.
PC-42236	BM212 MmpL3 inhibitor	BM212 is a novel antitubercular agent that possesses strong inhibitory activity against both Mycobacterium tuberculosis (MIC=0.7-1.5 ug/ml) and some nontuberculosis mycobacteria, inhibits transport activity of MmpL3.
PC-45367	Fidaxomicin Antibiotic	Fidaxomicin (OPT-80, PAR-101) is a new class of narrow spectrum macrocyclic antibiotic drug and RNA polymerase inhibitor, shows potent anti-Clostridium difficile activity with MIC90 of 0.12 ug/mL.

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