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Chemical Structure : Zoliflodacin
CAS No.: 1620458-09-4
Catalog No.: PC-60475Not For Human Use, Lab Use Only.
Zoliflodacin (AZD0914, ETX0914) is a novel DNA gyrase inhibitor that inhibits bacterial DNA biosynthesis, has potent in vitro activity against many different bacterial species with MIC of 0.004 to 0.25 ug/ml.
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|---|---|---|---|
| 1 mg | $128 | In stock | |
| 5 mg | $278 | In stock | |
| 10 mg | $428 | In stock | |
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Zoliflodacin (AZD0914, ETX0914) is a novel DNA gyrase inhibitor that inhibits bacterial DNA biosynthesis, has potent in vitro activity against many different bacterial species with MIC of 0.004 to 0.25 ug/ml.
Zoliflodacin has the MIC90s for C. trachomatis and C. pneumoniaeare 0.25 ug/ml and 1 ug/ml, respectively, and the MBC90s are 0.5 ug/ml for C. trachomatis and 2 ug/ml for C. pneumoniae.
| M.Wt | 487.44 | |
| Formula | C22H22FN5O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2R,4S,4aS)-11-fluoro-2,4-dimethyl-8-((S)-4-methyl-2-oxooxazolidin-3-yl)-1,2,4,4a-tetrahydro-2'H,6H-spiro[isoxazolo[4,5-g][1,4]oxazino[4,3-a]quinoline-5,5'-pyrimidine]-2',4',6'(1'H,3'H)-trione |
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1. Jacobsson S, et al. Antimicrob Agents Chemother. 2014 Sep;58(9):5585-8.
2. Kohlhoff SA, et al. Antimicrob Agents Chemother. 2014 Dec;58(12):7595-6.
3. Huband MD, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):467-74.
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