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GSK1322322

Chemical Structure : GSK1322322

CAS No.: 1152107-25-9

GSK1322322 (Lanopepden, GSK322)

Catalog No.: PC-70018Not For Human Use, Lab Use Only.

Lanopepden (GSK1322322) is a novel antibacterial agent that targets bacterial peptide deformylase (PDF), inhibits PDF activity and prevents bacterial protein synthesis.

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    Biological Activity

    Lanopepden (GSK1322322) is a novel antibacterial agent that targets bacterial peptide deformylase (PDF), inhibits PDF activity and prevents bacterial protein synthesis.
    Lanopepden (GSK1322322) demonstrates in vitro activity against MDR respiratory and skin infection pathogens, including MDR Streptococcus pneumoniae and MRSA.
    Lanopepden (GSK1322322) inhibits S. pneumoniae ATCC 49619 with MIC of 0.12-0.5 ug/mL.

    Physicochemical Properties

    M.Wt 479.56
    Formula C22H34FN7O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-((R)-2-(cyclopentylmethyl)-3-(2-(5-fluoro-6-((S)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl)-2-methylpyrimidin-4-yl)hydrazinyl)-3-oxopropyl)-N-hydroxyformamide

    References

    1. Ross JE, et al. J Clin Microbiol. 2011 Nov;49(11):3928-30.

    2. Arat S, et al. Antimicrob Agents Chemother. 2015 Feb;59(2):1182-92.

    3. O'Dwyer K, et al. Antimicrob Agents Chemother. 2013 May;57(5):2333-42.

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