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Chemical Structure : RWJ-49815
Catalog No.: PC-70181Not For Human Use, Lab Use Only.
RWJ-49815 is a potent bactericidal agent that inhibits the KinA autophosphorylation with IC50 of 1.6 uM.
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RWJ-49815 is a potent bactericidal agent that inhibits the KinA autophosphorylation with IC50 of 1.6 uM.
RWJ-49815 inhibits the autophosphorylation of kinase A of the KinA-Spo0F two-component signal transduction system in vitro.
RWJ-49815 suppresses growth of MRSA, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus pneumoniae (MICs=1-2 ug/ml).
RWJ-49815 exhibits reduced resistance emergence in a laboratory passage experiment compared with quinolone and ciprofloxacin.
| M.Wt | 449.598 | |
| Formula | C30H31N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Barrett JF, et al. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5317-22.
2. Stephenson K, et al. J Biol Chem. 2000 Dec 8;275(49):38900-4.
3. Theodorou EC, et al. Cell Signal. 2011 Aug;23(8):1327-37.
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