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BRD4592

Chemical Structure : BRD4592

CAS No.: 2109805-80-1

BRD4592 (BRD-4592)

Catalog No.: PC-70214Not For Human Use, Lab Use Only.

BRD4592 is a small-molecule, allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase (TrpAB), binds at the TrpAB α-β-subunit interface with IC50 of 70.9 nM and 22.6 nM for α-subunit and β-subunit, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BRD4592 is a small-molecule, allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase (TrpAB), binds at the TrpAB α-β-subunit interface with IC50 of 70.9 nM and 22.6 nM for α-subunit and β-subunit, respectively.
    BRD4592 is highly effective in vivo.

    Physicochemical Properties

    M.Wt 282.318
    Formula C17H15FN2O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (2R,3S,4R)-3-(2'-fluoro-[1,1'-biphenyl]-4-yl)-4-(hydroxymethyl)azetidine-2-carbonitrile

    References

    1. Chekler EL, et al. Chem Biol. 2015 Dec 17;22(12):1588-96.

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