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Ribocil

Chemical Structure : Ribocil

CAS No.: 1381289-58-2

Ribocil

Catalog No.: PC-45637Not For Human Use, Lab Use Only.

Ribocil is a synthetic mimic of riboflavin 5’-monophosphate (FMN) that competes with the natural ligand to inhibit FMN riboswitch-mediated expression of ribB.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Ribocil is a synthetic mimic of riboflavin 5’-monophosphate (FMN) that competes with the natural ligand to inhibit FMN riboswitch-mediated expression of ribB.
Ribocil depletes cellular levels of riboflavin with an IC50 value of 0.3 µM and inhibits E. coli growth with an MIC value of 2 ug/ml.

Physicochemical Properties

M.Wt 382.4826
Formula C19H22N6OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4(3H)-Pyrimidinone, 2-[1-[[2-(methylamino)-5-pyrimidinyl]methyl]-3-piperidinyl]-6-(2-thienyl)-

References

1. Howe JA, et al. Nature. 2015 Oct 29;526(7575):672-7.

2. Hermann T. Nature. 2015 Oct 29;526(7575):650-1.

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