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KKL-35

Chemical Structure : KKL-35

CAS No.: 865285-29-6

KKL-35 (KKL 35;KKL35)

Catalog No.: PC-70354Not For Human Use, Lab Use Only.

A small molecule inhibitor of trans-translation that has broad-spectrum antibiotic activity.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A small molecule inhibitor of trans-translation that has broad-spectrum antibiotic activity; inhibits the trans-translation tagging reaction with an IC50 of 0.9 uM; exhibits broad-spectrum antibiotic activity, validating trans-translation as a target for drug development.

Physicochemical Properties

M.Wt 317.7
Formula C15H9ClFN3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-chloro-N-(1-propyl-1H-tetrazol-5-yl)benzamide

References

1. Ramadoss NS, et al. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10282-7.

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