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Azathramycin

Chemical Structure : Azathramycin

CAS No.: 76801-85-9

Azathramycin (Azaerythromycin A, Desmethyl Azithromycin)

Catalog No.: PC-45263Not For Human Use, Lab Use Only.

Azathramycin is a macrolide antibiotic that effectively inhibits tumor angiogenesis by suppressing VEGFR2-mediated signaling pathways in lung cancer.

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Biological Activity

Azathramycin is a macrolide antibiotic that effectively inhibits tumor angiogenesis by suppressing VEGFR2-mediated signaling pathways in lung cancer.
Azathramycin enhances paclitaxel and cisplatin in non-small cell lung cancer.

Physicochemical Properties

M.Wt 734.9579
Formula C37H70N2O12
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,1

References

1. Li F, et al. Oncol Lett. 2017 Jul;14(1):89-96.

2. Chu DJ, et al. Genet Mol Res. 2014 Apr 14;13(2):2796-805.

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