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Fidaxomicin

Chemical Structure : Fidaxomicin

CAS No.: 873857-62-6

Fidaxomicin (OPT-80, PAR-101)

Catalog No.: PC-45367Not For Human Use, Lab Use Only.

Fidaxomicin (OPT-80, PAR-101) is a new class of narrow spectrum macrocyclic antibiotic drug and RNA polymerase inhibitor, shows potent anti-Clostridium difficile activity with MIC90 of 0.12 ug/mL.

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Biological Activity

Fidaxomicin (OPT-80, PAR-101) is a new class of narrow spectrum macrocyclic antibiotic drug and RNA polymerase inhibitor, shows potent anti-Clostridium difficile activity with MIC90 of 0.12 ug/mL.
Fidaxomicin treatmen induced selective eradication of pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria.

Physicochemical Properties

M.Wt 1058.039
Formula C52H74Cl2O18
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 33 mg/mL

Chemical Name/SMILES

Oxacyclooctadeca-3,5,9,13,15-pentaen-2-one, 3-[[[6-deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-D-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-D-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1

References

1. Poxton IR, et al. Future Microbiol. 2010 Apr;5(4):539-48.
2. Ackermann G, et al. Antimicrob Agents Chemother. 2004 Jun;48(6):2280-2.

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